2022
Journal articles
- ref_biblio
- Ida Cerqua, Konstantin Neukirch, Michela Terlizzi, Elisabetta Granato, Elisabetta Caiazzo, et al.. A vitamin E long-chain metabolite and the inspired drug candidate α-amplexichromanol relieve asthma features in an experimental model of allergen sensitization. Pharmacological Research, 2022, 181, pp.106250. ⟨10.1016/j.phrs.2022.106250⟩. ⟨hal-03788166⟩
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- ref_biblio
- Gabriele Möller, Veronika Temml, Antonio Cala Peralta, Océane Gruet, Pascal Richomme, et al.. Analogues of Natural Chalcones as Efficient Inhibitors of AKR1C3. Metabolites, 2022, 12 (2), pp.99. ⟨10.3390/metabo12020099⟩. ⟨hal-03716164⟩
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- ref_biblio
- Gabriele Möller, Veronika Temml, Antonio Cala Peralta, Océane Gruet, Pascal Richomme, et al.. Analogues of Natural Chalcones as Efficient Inhibitors of AKR1C3. Metabolites, 2022, 12 (2), pp.99. ⟨10.3390/metabo12020099⟩. ⟨hal-03782968⟩
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- ref_biblio
- Christian Kretzer, Paul Jordan, Katharina P.L. Meyer, Daniel Hoff, Markus Werner, et al.. Natural chalcones elicit formation of specialized pro-resolving mediators and related 15-lipoxygenase products in human macrophages. Biochemical Pharmacology, 2022, 195, pp.114825. ⟨10.1016/j.bcp.2021.114825⟩. ⟨hal-03533844⟩
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- ref_biblio
- Jimmy Josué Ceballos-Cruz, Jean-Jacques Helesbeux, Guillaume Viault, Denis Seraphin, Gumersindo Mirón-López, et al.. Photochemical Transformations of Chalcone-Vitamin E Hybrids. Journal of the Mexican Chemical Society, 2022, 66 (1), ⟨10.29356/jmcs.v66i1.1670⟩. ⟨hal-03533848⟩
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2021
Journal articles
- ref_biblio
- Konstantin Neukirch, Khaled Alsabil, Chau-Phi Dinh, Rossella Bilancia, Martin Raasch, et al.. Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor that Limits Inflammation. Journal of Medicinal Chemistry, 2021, 64 (15), pp.11496-11526. ⟨10.1021/acs.jmedchem.1c00806⟩. ⟨hal-03783673⟩
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- ref_biblio
- Guillaume Viault, Marie Kempf, Alexia Ville, Khaled Alsabil, Rodolphe Perrot, et al.. Semisynthetic Vitamin E Derivatives as Potent Antibacterial Agents against Resistant Gram‐Positive Pathogens. ChemMedChem, 2021, 16 (5), pp.881-890. ⟨10.1002/cmdc.202000792⟩. ⟨hal-03191789⟩
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2020
Journal articles
- ref_biblio
- Chau-Phi Dinh, Alexia Ville, Konstantin Neukirch, Guillaume Viault, Veronika Temml, et al.. Structure-based design, semi-synthesis and anti-inflammatory activity of tocotrienolic amides as 5-lipoxygenase inhibitors. European Journal of Medicinal Chemistry, 2020, 202, pp.112518. ⟨10.1016/j.ejmech.2020.112518⟩. ⟨hal-02884134⟩
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2019
Journal articles
- ref_biblio
- Nadjet Mezache, Séverine Derbré, Hocine Laouer, Pascal Richomme, Denis Seraphin, et al.. Senecipyrrolidine, an unusual pyrrolidine alkaloid isolated from Jacobaea gigantea (Desf.) Pelser (Asteraceae). Natural Product Research, 2019, 33 (15), pp.2182-2191. ⟨10.1080/14786419.2018.1493584⟩. ⟨hal-02435027⟩
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- ref_biblio
- Alexia Ville, Guillaume Viault, Jean-Jacques Helesbeux, David Guilet, Pascal Richomme, et al.. Efficient Semi-Synthesis of Natural δ-( R )-Tocotrienols from a Renewable Vegetal Source. Journal of Natural Products, 2019, 82 (1), pp.51-58. ⟨10.1021/acs.jnatprod.8b00517⟩. ⟨hal-02358466⟩
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Conference papers
- ref_biblio
- Séverine Derbré, Luc Séro, Antoine Bruguière, Patricia Blanchard, J. Leguy, et al.. Anti-ageing NPs: screening and identification in mixtures using 13C-NMR.. 4th International Symposium: Analytical Chemistry Research & Development and Quality Control of Health Products., Oct 2019, Bordeaux, France. ⟨hal-02863586⟩
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- ref_biblio
- Chau-Phi Dinh, Alexia Ville, Barbe Anaïs, Thuy-Linh To, Konstantin Neukirch, et al.. Structure-based modeling, semisynthesis and biological evaluations of garcinoic acid derivatives. Journée Des Doctorants de la SFR QUASAV, Oct 2019, Angers, France. ⟨hal-02794835⟩
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- ref_biblio
- Chau-Phi Dinh, Alexia Ville, Barbe Anaïs, Thuy-Linh To, Konstantin Neukirch, et al.. Molecular docking, semisynthesis and biological evaluations of garcinoic acid amides as 5-lipoxygenase inhibitors. 27th Annual GP2A Medicinal Chemistry Conference, Aug 2019, Nottingham, United Kingdom. pp.179, ⟨10.3390/ph12040179⟩. ⟨hal-02794994⟩
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- ref_biblio
- Chau-Phi Dinh, Alexia Ville, Barbe Anaïs, Thuy-Linh To, Konstantin Neukirch, et al.. Anti-inflammatory activity of vitamin E derivatives. Journée Des Doctorants de l’ED EGAAL, Jul 2019, Rennes, France. ⟨hal-02795186⟩
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Book sections
- ref_biblio
- Andreas Schinkovitz, Denis Seraphin, Pascal Richomme. New Developments of Laser Desorption Ionization Mass Spectrometry in Natural Products Research. Encyclopedia of Analytical Chemistry: Applications, Theory and Instrumentation, 30, Wiley, 2019, 9780471976707. ⟨10.1002/9780470027318.a9917.pub2⟩. ⟨hal-02560841⟩
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Poster communications
- ref_biblio
- Veronika Temml, Helmut Pein, Simona Pace, Ulrike Garscha, Birgit Waltenberger, et al.. Computational Investigation of multi-target effects in the arachidonic acid cascade on the example of potent natural 5-LO inhibitor garcinoic acid. 67th Annual Conference of the Society for Medicinal Plant and Natural Product Research, Sep 2019, Innsbruck, Austria. ⟨hal-02864513⟩
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- ref_biblio
- Konstantin Neukirch, Antonietta Rossi, Martin Raasch, Simona Pace, Denis Seraphin, et al.. The vitamin E derivative α-amplexichromanol as anti-inflammatory lead inspired from traditional african medicine. 67th Annual Conference of the Society for Medicinal Plant and Natural Product Research, Sep 2019, Innsbruck, Austria. ⟨hal-02864518⟩
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- ref_biblio
- Antonio Cala Peralta, Fabian Mayr, Guillaume Viault, Veronika Temml, Daniela Schuster, et al.. From Phloridzin towards Semisynthetic Bioactive Dihydrochalcones. 27th Annual GP2A Medicinal Chemistry Conference, Aug 2019, Notthingham, United Kingdom. Pharmaceuticals, 12 (4), pp.179, 2019, ⟨10.3390/ph12040179⟩. ⟨hal-02798004⟩
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- ref_biblio
- Antonio Cala Peralta, Fabian Mayr, Guillaume Viault, Veronika Temml, Daniela Schuster, et al.. SEMISYNTHESIS OF BIOACTIVE C-BENZYLATED
DIHYDROCHALCONES FROM RENEWABLE SOURCES. RICT 2019 - Interfacing Chemical Biology and Drug Discovery - 55th International Conference on Medicinal Chemistry, Jul 2019, Nantes, France. ⟨hal-02798163⟩
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- ref_biblio
- Chau-Phi Dinh, Alexia Ville, Anaïs Barbe, Thuy Linh To, Guillaume Viault, et al.. Anti-inflammatory activity of w-oxidized tocotrienols. 26th Young Research Fellows Meeting, Feb 2019, Paris, France. ⟨hal-02796842⟩
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2018
Journal articles
- ref_biblio
- Andreas Schinkovitz, Pierre Le Pogam, Séverine Derbré, Emilie Vessieres, Patricia Blanchard, et al.. Secondary metabolites from lichen as potent inhibitors of advanced glycation end products and vasodilative agents. Fitoterapia, 2018, 131, pp.182-188. ⟨10.1016/j.fitote.2018.10.015⟩. ⟨hal-01903310⟩
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- ref_biblio
- Guillaume Viault, Jean-Jacques Helesbeux, Pascal Richomme, Denis Seraphin. Concise semisynthesis of novel phenazine-vitamin E hybrids via regioselective tocopheryl ortho-quinone formation. Tetrahedron Letters, 2018, 59 (27), pp.2627-2630. ⟨10.1016/j.tetlet.2018.05.011⟩. ⟨hal-02521254⟩
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- ref_biblio
- Helmut Pein, Alexia Ville, Simona Pace, Veronika Temml, Ulrike Garscha, et al.. Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase. Nature Communications, 2018, 9 (1), pp.3834. ⟨10.1038/s41467-018-06158-5⟩. ⟨hal-02521285⟩
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Conference papers
- ref_biblio
- Chau-Phi Dinh, Guillaume Viault, Andreas Koeberle, Hermann Stuppner, Daniela Schuster, et al.. Design, semisynthesis and biological evaluations of garcinoic acid derivatives as novel anti-inflammatory agents. 25th Young Research Fellows Meeting, Mar 2018, Orléans, France. ⟨hal-02796904⟩
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Patents
- ref_biblio
- Denis Seraphin, David Guilet, Andreas Schinkovitz, Pascal Richomme, Marylène Dias, et al.. Matrix for specific detection of alkaloids by MALDI-TOF mass spectrometry. France, N° de brevet: FR 3065214 A1 20181019. 2018. ⟨hal-02521299⟩
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Poster communications
- ref_biblio
- Alexia Ville, Guillaume Viault, Jean-Jacques Helesbeux, Denis Seraphin. Semisynthetic pathways starting from δ-garcinoic acid towards anti-inflammatory tocotrienols isolated from New Caledonian endemic plants. Journées des doctorants de la SFR QUASAV, 11ème édition, Oct 2018, Angers, France. ⟨hal-02864443⟩
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- ref_biblio
- Helmut Pein, Simona Pace, Veronika Temml, Ulrike Garscha, Birgit Waltenberger, et al.. Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase. 7th European Workshop on Lipid Mediators, Sep 2018, Bruxelles, Belgium. ⟨hal-02864504⟩
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- ref_biblio
- Helmut Pein, Simona Pace, Veronika Temml, Ulrike Garscha, Birgit Waltenberger, et al.. Omega-oxidized terpenoids: from traditional African medicine to novel insights into human vitamin physiology. 24th Conference on Isoprenoids, Sep 2018, Bialystok, Poland. ⟨hal-02864499⟩
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- ref_biblio
- Veronika Temml, Helmut Pein, Simona Pace, Ulrike Garscha, Birgit Waltenberger, et al.. Computational analysis of the interaction between vitamin E derivatives and 5-lipoxygenase. Paracelsus Science Get Together, Jun 2018, Salzbourg, Austria. ⟨hal-02864497⟩
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- ref_biblio
- Chau-Phi Dinh, Jean-Jacques Helesbeux, Andreas Koeberle, Daniela Schuster, Oliver Werz, et al.. 26th Annual GP2A Medicinal Chemistry Conference & 32nd Journées Franco-Belges de Pharmacochimie. Joint 26th GP2A/ 32nd JFB Conferences, Jun 2018, Asnelles sur Mer, France. MDPI, Pharmaceuticals, 12 (2), pp.73, 2019, ⟨10.3390/ph12020073⟩. ⟨hal-02796872⟩
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- ref_biblio
- Alexia Ville, Khaled Alsabil, Guillaume Viault, David Guilet, Jean-Jacques Helesbeux, et al.. α-amplexichromanol, a vitamin E semisynthetic analog – Valorization of its anti-inflammatory potential. Journée thématique de la SFR ICAT4208, May 2018, Angers, France. ⟨hal-02864434⟩
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- ref_biblio
- Guillaume Viault, Abdel Benamar, Morgane Le Mao, R. Andriantsitohaina, Jean-Jacques Helesbeux, et al.. Synthèse et évaluation biologique de nouveaux actifs potentiels ciblant les dysfonctionnements mitochondriaux. Journée thématique de la SFR ICAT, May 2018, Angers, France. ⟨hal-02797199⟩
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- ref_biblio
- Alexia Ville, Guillaume Viault, Jean-Jacques Helesbeux, Denis Seraphin, Pascal Richomme. Semisynthetic pathways towards anti-inflammatory tocotrienols isolated from new-caledonian endemic plants. 14a. RIIPN (14a Reunión Internacional de Productos Naturales), May 2018, Cuernavaca Morelos, Mexico. ⟨hal-02864440⟩
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- ref_biblio
- Alexia Ville, Guillaume Viault, Jean-Jacques Helesbeux, David Guilet, Pascal Richomme, et al.. Semisynthesis of δ-(R)-tocotrienols. 8ème Symposium Francophone de Synthèse Totale, May 2018, Bordeaux, France. ⟨hal-02797021⟩
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- ref_biblio
- Andreas Koeberle, Helmut Pein, Simona Pace, Veronika Temml, Ulrike Garscha, et al.. Semi-synthetic derivatives and endogenous metabolites of vitamin E as potent, selective and orally available inhibitors of 5 lipoxygenase. Frontiers in Medicinal Chemistry, Mar 2018, Iéna, Germany. ⟨hal-02864495⟩
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- ref_biblio
- Veronika Temml, Andreas Koeberle, Ulrike Garscha, Jean-Jacques Helesbeux, Birgit Waltenberger, et al.. Computational binding mode prediction of ω-oxidized tocotrienols as inhibitors of 5-lipoxygenase. Phyto-Valley 1st Austrian Summit on Natural Products, Jan 2018, Seefeld, Austria. ⟨hal-02864486⟩
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- ref_biblio
- Andreas Koeberle, Helmut Pein, Simona Pace, Veronika Temml, Ulrike Garscha, et al.. Garcinia species are potent and selective, allosteric inhibitors of 5-lipoxygenase and provide novel insights into human vitamin E physiology. Phyto-Valley 1st Austrian Summit on Natural Products, Jan 2018, Seefeld, Austria. ⟨hal-02864490⟩
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2017
Journal articles
- ref_biblio
- Amel Achouri, Séverine Derbré, Kamel Medjroubi, Hocine Laouer, Denis Seraphin, et al.. Two new triterpenoid saponins from the leaves of Bupleurum lancifolium ( Apiaceae ). Natural Product Research, 2017, 31 (19), pp.2286-2293. ⟨10.1080/14786419.2017.1324960⟩. ⟨hal-02435056⟩
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- ref_biblio
- Khaled Alsabil, Guillaume Viault, Sorphon Suor-Cherer, Jean-Jacques Helesbeux, Joumaa Merza, et al.. Efficient ortho-formylation in vitamin E series, application to the semi-synthesis of natural 5- and 7-formyl-δ-tocotrienols revealing an unprecedented 5-bromo-7-formyl exchange. Tetrahedron, 2017, 73 (49), pp.6863-6870. ⟨10.1016/j.tet.2017.10.039⟩. ⟨hal-02521270⟩
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- ref_biblio
- Ali Jaber, Denis Seraphin, David Guilet, Junichi Osuga, Edmond Cheble, et al.. Bithiophenic MALDI matrices as valuable leads for the selective detection of alkaloids. Analytical and Bioanalytical Chemistry, 2017, 409 (29), pp.6791-6801. ⟨10.1007/s00216-017-0634-x⟩. ⟨hal-02521281⟩
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Conference papers
- ref_biblio
- Alexia Ville, Guillaume Viault, Jean-Jacques Helesbeux, Denis Seraphin. Hémisynthèse d’analogues originaux de la vitamine E à visée anti-inflammatoire. Journée des doctorants de la SFR QUASAV, 10e édition, Oct 2017, Angers, France. ⟨hal-02864455⟩
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- ref_biblio
- Jean-Jacques Helesbeux, Khaled Alsabil, Alexia Ville, Sorphon Suor-Cherer, Guillaume Viault, et al.. Towards an Alternative to NSAIDs Based on Vitamin E Analogues. 25th Conference of GP2A, Aug 2017, Liverpool, United Kingdom. pp.97, ⟨10.3390/ph10040097⟩. ⟨hal-02797756⟩
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- ref_biblio
- Alexia Ville, Guillaume Viault, Jean-Jacques Helesbeux, Denis Seraphin. Semisynthetic pathways starting from δ-garcinoic acid towards anti-inflammatory tocotrienols isolated from New Caledonian endemic plants. 5th AFERP International Conference "Pharmacognosy from here and there", Jul 2017, Angers, France. ⟨hal-02864451⟩
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- ref_biblio
- Alexia Ville, Guillaume Viault, Jean-Jacques Helesbeux, Denis Seraphin. Towards pharmacologically active tocotrienol derivatives starting from δ-garcinoic acid as a common natural precursor. 24th Young Research Fellow’s Meeting, Feb 2017, Châtenay-Malabry, France. ⟨hal-02864430⟩
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- ref_biblio
- Mickaël Lecomte, Latifa Hamama, Linda Voisine, Julia Gatto, Jean-Jacques Helesbeux, et al.. Influence of fungal exudates of Alternaria dauci on carrot partial resistance. International Symposium on Carrot and Other Apiaceae, International Society for Horticultural Science (ISHS). INT., 2017, Angers, France. pp.231-236, ⟨10.17660/ActaHortic.2017.1153.34⟩. ⟨hal-02516581⟩
- Accès au bibtex
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Patents
- ref_biblio
- Pascal Richomme, Jean-Jacques Helesbeux, David Guilet, Denis Seraphin, Hermann Stuppner, et al.. Preparation of tocotrienol derivatives, pharmaceutical composition and method of use in 5-lipoxygenase related diseases. France, Patent n° : WO 2017032881 A1 20170302. 2017. ⟨hal-02866630⟩
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Poster communications
- ref_biblio
- Alexia Ville, Guillaume Viault, Jean-Jacques Helesbeux, Denis Seraphin. Semisynthetics Pathways Starting from δ-Garcinoic Acid towards Anti-Inflammatory Tocotrienols Isolated from New-Caledonian Endemic Plants. 25th Conference of GP2A, Aug 2017, Liverpool, United Kingdom. Pharmaceuticals, 10 (4), pp.97, 2017, ⟨10.3390/ph10040097⟩. ⟨hal-02797913⟩
- Accès au bibtex
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- ref_biblio
- Khaled Alsabil, Sorphon Suor-Cherer, H. Y. Lam, Guillaume Viault, Jean-Jacques Helesbeux, et al.. Extraction and Purification of δ-Tocotrienol from Bixa orellana and Semi-Synthesis of 7-Formyl-δ-tocotrienol. 25th Conference of GP2A, Aug 2017, Liverpool, United Kingdom. Pharmaceuticals, 10 (4), pp.97, 2017, ⟨10.3390/ph10040097⟩. ⟨hal-02797856⟩
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2016
Journal articles
- ref_biblio
- Khaled Alsabil, Sorphon Suor-Cherer, Andreas Koeberle, Guillaume Viault, Alexis Lavaud, et al.. Semisynthetic and Natural Garcinoic Acid Isoforms as New mPGES-1 Inhibitors. Planta Medica, 2016, 82 (11/12), pp.1110-1116. ⟨10.1055/s-0042-108739⟩. ⟨hal-01391940⟩
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Conference papers
- ref_biblio
- Alexia Ville, Guillaume Viault, Jean-Jacques Helesbeux, Denis Seraphin. Hémisynthèse de nouveaux analogues de la vitamine E à visée anti-inflammatoire. Séminaire recherche du département Pharmacie, Faculté de Santé, Université d’Angers, Sep 2016, Angers, France. ⟨hal-02864459⟩
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- ref_biblio
- Andreas Schinkovitz, Ali Jaber, Séverine Boisard, Annika Koch, Klaus Dreisewerd, et al.. Laser Desorption Ionization and Related Methods for the Detection of Small Molecules. 24th GP2A Conference (Groupement de Pharmacochimist de l'Arc Atlantique), Aug 2016, Angers, France. ⟨10.3390/ph10010017⟩. ⟨hal-02521289⟩
- Accès au texte intégral et bibtex
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Poster communications
- ref_biblio
- Alexia Ville, Guillaume Viault, Jean-Jacques Helesbeux, Denis Seraphin. δ-garcinoic acid, a platform to tocotrienol derivatives isolated from barks of New Caledonian endemics plants. 5e journées scientifiques de l’école doctorale VENAM, Nov 2016, Nantes, France. ⟨hal-02864424⟩
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- ref_biblio
- Khaled Alsabil, Sorphon Suor-Cherer, Andreas Koeberle, Guillaume Viault, Daniela Schuster, et al.. mPGES-1 as a New Target for Garcinoic Acid Isoforms. The 24th Conference” of the Groupement des Pharmacochimistes de l’Arc Atlantique (GP2A), Aug 2016, Angers, France. Pharmaceuticals, 10 (1), pp.17, 2017, ⟨10.3390/ph10010017⟩. ⟨hal-02797636⟩
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- ref_biblio
- Alexia Ville, Guillaume Viault, Jean-Jacques Helesbeux, Denis Seraphin. δ-Garcinoic Acid, a Convenient Natural Precursor to the Attractive δ-Tocotrienol. The 24th Conference” of the Groupement des Pharmacochimistes de l’Arc Atlantique (GP2A), Aug 2016, Angers, France. Pharmaceuticals, 10 (1), pp.17, 2017, ⟨10.3390/ph10010017⟩. ⟨hal-02797528⟩
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- ref_biblio
- Ali Jaber, Andreas Schinkovitz, David Guilet, Pascal Richomme, Denis Seraphin. Bithiophenic Matrix for Selective Detection and Quantification of Toxic Alkaloids by MALDI-TOF-MS. The 24th Conference of the Groupement des Pharmacochimistes de l’Arc Atlantique (GP2A), Aug 2016, Angers, France. Pharmaceuticals, 10 (1), pp.17, 2017, ⟨10.3390/ph10010017⟩. ⟨hal-02797464⟩
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2015
Journal articles
- ref_biblio
- Bach Tai Dang, Caroline Rouger, Marc Litaudon, Denis Seraphin, Pascal Richomme, et al.. Identification of Minor Benzoylated 4-Phenylcoumarins from a Mammea neurophylla Bark Extract. Molecules, 2015, 20 (10), pp.17735-17746. ⟨10.3390/molecules201017735⟩. ⟨hal-01391951⟩
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- ref_biblio
- Bach Tai Dang, Yann Guitton, Ingrid Freuze, Olivier Grovel, Marc Litaudon, et al.. Dereplication of Mammea neurophylla metabolites to isolate original 4-phenylcoumarins.. Phytochemistry Letters, 2015, 11, pp.61-68. ⟨10.1016/j.phytol.2014.11.011⟩. ⟨hal-02861863⟩
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Poster communications
- ref_biblio
- Ali Jaber, Andreas Schinkovitz, Ghislain Kenfack, Pascal Richomme, Denis Seraphin. Maldi detection of alkaloids by bithiophenic matrices. 23rd Conference of the Groupement des Pharmacochimistes de l’Arc Atlantique (GP2A), Aug 2015, Munster, Germany. Pharmaceuticals, 9 (1), pp.1, 2016, ⟨10.3390/ph9010001⟩. ⟨hal-02864376⟩
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- ref_biblio
- Khaled Alsabil, Jean-Jacques Helesbeux, Denis Seraphin. Semisynthesis of natural formylated tocotrienols. 23rd Conference of the Groupement des Pharmacochimistes de l’Arc Atlantique (GP2A), Aug 2015, Munster, Germany. Pharmaceuticals, 9 (1), pp.1, 2016, ⟨10.3390/ph9010001⟩. ⟨hal-02864395⟩
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2014
Journal articles
- ref_biblio
- Bach Tai Dang, Charlotte Gény, Patricia Blanchard, Caroline Rouger, Pierre Tonnerre, et al.. Advanced glycation inhibition and protection against endothelial dysfunction induced by coumarins and procyanidins from Mammea neurophylla.. Fitoterapia, 2014, 96, pp.65-75. ⟨10.1016/j.fitote.2014.04.005⟩. ⟨hal-01059141⟩
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- ref_biblio
- Emiliane Taillebois, Paul Langlois, Thomas Cunha, Denis Seraphin, Steeve H Thany. Synthesis and biological activity of fluorescent neonicotinoid insecticide thiamethoxam. Bioorganic and Medicinal Chemistry Letters, 2014, 24 (15), pp.3552-3555. ⟨10.1016/j.bmcl.2014.05.052⟩. ⟨hal-02641484⟩
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- ref_biblio
- Mickaël Lecomte, Latifa Hamama, Linda Voisine, Julia Gatto, Jean-Jacques Helesbeux, et al.. Partial Resistance of Carrot to Alternaria dauci Correlates with In Vitro Cultured Carrot Cell Resistance to Fungal Exudates. PLoS ONE, 2014, 9 (7), pp.e101008. ⟨10.1371/journal.pone.0101008⟩. ⟨hal-01128311⟩
- Accès au texte intégral et bibtex
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Book sections
- ref_biblio
- Andreas Schinkovitz, Denis Seraphin, Pascal Richomme, Robert Meyers. New Developments of Laser Desorption Ionization Mass Spectrometry in Plant Analysis. Encyclopedia of Analytical Chemistry: Applications Theory and Instrumentation, 1, Wiley, pp.411-424, 2014, 9780470027318. ⟨10.1002/9780470027318.a9917⟩. ⟨hal-03247958⟩
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Poster communications
- ref_biblio
- Amel Achouri, Salah Akkal, Séverine Derbré, Kamel Medjroubi, Hocine Laouer, et al.. Anti-AGE algerian vegetal extracts. Phytochemical study of Bupleurum lancifolium (Apiaceae). 5th International Chemistry Conference, 2014, Abha, Saudi Arabia. 2014. ⟨hal-03247885⟩
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- ref_biblio
- Mickaël Lecomte, Latifa Hamama, Linda Voisine, Julia Gatto, Jean-Jacques Helesbeux, et al.. Lien entre résistance partielle à Alternaria dauci et résistance aux toxines fongiques chez la carotte. 10èmes Rencontres de Phytopathologie- Mycologie, 2014, Aussois, France. 2014. ⟨hal-03281870⟩
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- ref_biblio
- Amel Achouri, Salah Akkal, Kamel Medjroubi, Denis Seraphin, Séverine Derbré. Screening of anti-AGE properties and dereplication of extracts from algerian medicinal plants. 22e GP2A meeting of the "Groupement des Pharmacochimistes de l'Arc Atlantique", 2014, Nantes, France. 2014. ⟨hal-03247872⟩
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- ref_biblio
- Khaled Alsabil, Jean-Jacques Helesbeux, Denis Seraphin. Semisynthetic modifications of δ-amplexichromanol, an original tocotrienol with antitumoral properties. 22èmes Conférences Européennes du Groupement des Pharmacochimistes de l’Arc Atlantique (GP2A), 2014, Nantes, France. 2014. ⟨hal-03247967⟩
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- ref_biblio
- Isabelle Baglin, Lizeth Bodero, Séverine Derbré, Patricia Blanchard, Dimitri Bréard, et al.. Phloroglucinol : a simple core for new anti-AGEs derivatives - synthesis, anti-AGEs activity and RSA. 22e GP2A meeting of the "Groupement des Pharmacochimistes de l'Arc Atlantique", 2014, Nantes, France. 2014. ⟨hal-03247874⟩
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2013
Journal articles
- ref_biblio
- Luc Séro, Lionel Sanguinet, Patricia Blanchard, Bach Tai Dang, Sylvie Morel, et al.. Tuning a 96-Well Microtiter Plate Fluorescence-Based Assay to Identify AGE Inhibitors in Crude Plant Extracts. Molecules, 2013, 18 (11), pp.14320 - 14339. ⟨10.3390/molecules181114320⟩. ⟨hal-03247638⟩
- Accès au texte intégral et bibtex
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- ref_biblio
- Luc Séro, Lionel Sanguinet, Séverine Derbré, Frank Boury, Guillaume Brotons, et al.. Fluorescent Self-Assembled Monolayers of Umbelliferone: A Relationship between Contact Angle and Fluorescence. Langmuir, 2013, 29 (33), pp.10423-10431. ⟨10.1021/la401536p⟩. ⟨hal-02541529⟩
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- ref_biblio
- Sylvie Morel, Jean-Jacques Helesbeux, Denis Séraphin, Séverine Derbré, Julia Gatto, et al.. Anti-AGEs and antiparasitic activity of an original prenylated isoflavonoid and flavanones isolated from Derris ferruginea. Phytochemistry Letters, 2013, 6 (3), pp.498-503. ⟨10.1016/j.phytol.2013.06.002⟩. ⟨hal-00911058⟩
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Patents
- ref_biblio
- Marylène Dias, Eric Levillain, Pascal Richomme, Andreas Schinkovitz, Denis Seraphin. New Use for a Compound as a Matrix in the Specific Detection, Identification and/or Quantification of Alkaloids by MALDI-TOF Mass Spectrometry. France, N° de brevet: Non spécifié. 2013. ⟨hal-03247670⟩
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Poster communications
- ref_biblio
- Amel Achouri, Zohra Belfadel, Salah Akkal, Kamel Medjroubi, Elisabeth Seguin, et al.. Selection of Algerian medicinal plants according to a screening of their anti-AGEs properties. AFERP & STOLON International Symposium, 2013, Bruxelles, Belgium. 2013. ⟨hal-03247875⟩
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- ref_biblio
- Bach Tai Dang, Séverine Derbré, Pascal Richomme, Denis Seraphin. New anti-AGE compounds from Mammea neurophylla (Calophyllaceae). International Conference on Natural Products Utilization: From Plants to Pharmacy Shelf, 2013, Bansko, Bulgaria. 2013. ⟨hal-03247890⟩
- Accès au bibtex
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- ref_biblio
- Hyacinthe Le Gall, Bach Tai Dang, Patricia Blanchard, Pascal Richomme, Denis Seraphin, et al.. Chemical engineering on Mammea neurophylla extract to improve anti-AGEs potential. AFERP & STOLON International Symposium, 2013, Bruxelles, Belgium. 2013. ⟨hal-03247873⟩
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2012
Journal articles
- ref_biblio
- Andreas Schinkovitz, Ghislain-Tsague Kenfack, Denis Seraphin, Eric Levillain, Marylène Dias, et al.. Selective detection of alkaloids in MALDI-TOF: the introduction of a novel matrix molecule. Analytical and Bioanalytical Chemistry, 2012, 403 (6), pp.1697 - 1705. ⟨10.1007/s00216-012-5958-y⟩. ⟨hal-01389233⟩
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- ref_biblio
- Andreas Schinkovitz, Ghislain-Tsague Kenfack, Denis Seraphin, Eric Levillain, Marylène Dias, et al.. Erratum to: Selective detection of alkaloids in MALDI-TOF: the introduction of a novel matrix molecule. Analytical and Bioanalytical Chemistry, 2012, 404 (2), pp.619-621. ⟨10.1007/s00216-012-6109-1⟩. ⟨hal-01390770⟩
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- ref_biblio
- Luc Séro, François Calard, Lionel Sanguinet, Eric Levillain, Pascal Richomme, et al.. Synthesis and evaluation of naphthoic acid derivatives as fluorescent probes to screen advanced glycation end-products breakers. Bioorganic and Medicinal Chemistry Letters, 2012, 22 (21), pp.6716 - 6720. ⟨10.1016/j.bmcl.2012.08.092⟩. ⟨hal-03027816⟩
- Accès au texte intégral et bibtex
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Conference papers
- ref_biblio
- Luc Séro, Séverine Derbré, Lionel Sanguinet, Pascal Richomme, Denis Seraphin. Mise au point d’un criblage automatisé d’inhibiteurs de la formation des AGEs applicable aux extraits végétaux. 3e Journée Inter-régionale de Chimie Moléculaire et Thérapeutique, 2012, Le Mans, France. ⟨hal-03247830⟩
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Poster communications
- ref_biblio
- Séverine Derbré, Bach Tai Dang, Ingrid Freuze, David Guilet, Anne-Marie Le Ray, et al.. Identification of coumarins in DCM bark, leaf and fruit extracts from Mammea neurophylla (Calophyllaceae) by LC-PDA-MSn. International Congress on Natural Products Research on Global Change, Natural Products and Human Health/8th Joint Meeting of AFERP, ASP, GA, PSE and SIF, 2012, New-York, United States. Planta Medica, 78 (11), p. 1260, 2012, ⟨10.1055/s-0032-1321213⟩. ⟨hal-03247438⟩
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- ref_biblio
- Isabelle Baglin, Thomas Cunha, Séverine Derbré, Julia Gatto, Patricia Blanchard, et al.. Anti-AGEs phloroglucinol derivatives. Synthesis, anti-AGEs and vaso-activity evaluation. RICT 2012 - Interfacing Chemical Biology and Drug Discovery, 2012, Poitiers, France. 2012. ⟨hal-03247871⟩
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2011
Journal articles
- ref_biblio
- Andreas Schinkovitz, Ghislain Tsague Kenfack, Eric Levillain, Marylène Dias, Jean-Jacques Helesbeux, et al.. Free and immobilized matrix molecules: impairing ionization by quenching secondary ion formation in laser desorption MS. Journal of Mass Spectrometry, 2011, 46 (9), pp.884 - 890. ⟨10.1002/jms.1965⟩. ⟨hal-03027839⟩
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- ref_biblio
- Ghislain Tsague Kenfack, Andreas Schinkovitz, Suresh Babu, Kamal Elouarzaki, Marylène Dias, et al.. Triazolobithiophene Light Absorbing Self-Assembled Monolayers: Synthesis and Mass Spectrometry Applications. Molecules, 2011, 16 (12), pp.8758 - 8774. ⟨10.3390/molecules16108758⟩. ⟨hal-03027827⟩
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Conference papers
- ref_biblio
- Luc Séro, Séverine Derbré, Lionel Sanguinet, Denis Seraphin. Formation d’AGEs sur support solide et caractérisation par fluorescence. Journées de l’école doctorale VENAM, 2011, Angers, France. ⟨hal-03247826⟩
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- ref_biblio
- Luc Séro, Lionel Sanguinet, Séverine Derbré, Denis Seraphin. Recherche d’inhibiteurs des réactions de glycation : du test à la molécule. SCF-BPL 2011 - Les Journées scientifiques de la Société Chimique de France, Section Bretagne - Pays de la Loire, 2011, Noirmoutier, France. ⟨hal-03287476⟩
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Poster communications
- ref_biblio
- Luc Séro, Séverine Derbré, Lionel Sanguinet, Denis Seraphin. Formation of AGEs in heterogeneous phase. The XXth meeting of the Groupement des Pharmacochimistes de l’Arc Atlantique (GP2A), 2011, Cork, Ireland. , 2011. ⟨hal-03287463⟩
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- ref_biblio
- Isabelle Baglin, C. Basle, E. N’stiba, Séverine Derbré, Julia Gatto, et al.. Benzophenone derivatives : From natural source to synthetic one. Synthesis and anti-AGEs activity. The XXth meeting of the Groupement des Pharmacochimistes de l’Arc Atlantique (GP2A), 2011, Cork, Ireland. 2011. ⟨hal-03247929⟩
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- ref_biblio
- Charlotte Gény, Séverine Derbré, Patricia Blanchard, Marc Litaudon, Pascal Richomme, et al.. Isolation and purification of anti-AGEs products from methanolic bark extract of Mammea neurophylla using bioguided fractionation. The XXth meeting of the Groupement des Pharmacochimistes de l’Arc Atlantique (GP2A), 2011, Cork, Ireland. 2011. ⟨hal-03247924⟩
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2010
Journal articles
- ref_biblio
- Benoit Pinel, Joëlle Dubois, Denis Séraphin, Pascal Richomme. Semisynthesis of alpha-methyl-gamma-lactones and in vitro evaluation of their activity on protein farnesyltransferase.. Journal of Enzyme Inhibition and Medicinal Chemistry, 2010, 25 (2), pp.172-9. ⟨10.3109/14756360903169592⟩. ⟨hal-00491746⟩
- Accès au bibtex
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- ref_biblio
- Séverine Derbré, Julia Gatto, Aude Pelleray, Laurie Coulon, Denis Seraphin, et al.. Automating a 96-well microtiter plate assay for advanced glycation end-products inhibitors or inducers identification: application to the screening of a small natural compounds library.. Analytical and Bioanalytical Chemistry, 2010, 398 (4), pp.1747-1758. ⟨10.1007/s00216-010-4065-1⟩. ⟨hal-01389234⟩
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Poster communications
- ref_biblio
- Luc Séro, Lionel Sanguinet, Séverine Derbré, Denis Seraphin. Mise au point d‟une nouvelle méthode de criblage sur support solide. "titre manquant", 2010, Paris, France. 2010. ⟨hal-03247639⟩
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- ref_biblio
- Séverine Derbré, Aude Pelleray, Denis Seraphin, Pascal Richomme. Automatisation d’un test de criblage en plaque 96 puits pour l’identification d’inhibiteurs des AGEs : application au criblage d’une petite chimiothèque de produits naturels. 17e journée Jeunes chercheurs de la Société de Chimie Thérapeutique, 2010, Paris, France. 2010. ⟨hal-03247919⟩
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- ref_biblio
- Isabelle Baglin, Anaïs Terrien, Antoine Garnier, Séverine Derbré, Julia Gatto, et al.. Synthesis and anti-AGEs testing of phloroglucinol derivatives. 19e rencontres européennes du groupement des pharmacochimistes de l’arc atlantique, 2010, Mont Saint Aignan, France. 2010. ⟨hal-03247916⟩
- Accès au bibtex
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- ref_biblio
- Luc Séro, Séverine Derbré, Christelle Gautier, Pascal Richomme, Lionel Sanguinet, et al.. Photophysical behavior of 4-methylumbelliferone’s SAM’s on different substrate. ElecMol'10 - 5th International Conference on Molecular Electronics, 2010, Grenoble, France. 2010. ⟨hal-03247825⟩
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- ref_biblio
- Luc Séro, Séverine Derbré, Pascal Richomme, Denis Seraphin. Development of a 96-wells plate screening in supporting phase. 19e rencontres européennes du groupement des pharmacochimistes de l’arc atlantique, 2010, Mont Saint Aignan, France. 2010. ⟨hal-03247928⟩
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2009
Journal articles
- ref_biblio
- Suresh Babu, G Tsagueken, Jacqueline Ropivia, Jean-Jacques Helesbeux, Séverine Derbré, et al.. A promising method for efficient analysis of secondary metabolites in plant extracts by a matrix-free Desorption/Ionization on self-Assembled Monolayer Surfaces (DIAMS) technique. Planta Medica, 2009, 75 (9), Non spécifié. ⟨10.1055/s-0029-1234850⟩. ⟨hal-03027834⟩
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- ref_biblio
- Nadjet Mezache, Séverine Derbré, Salah Akkal, Hocine Laouer, Denis Seraphin, et al.. Fast counter current chromatography of n-butanolic fraction from Senecio giganteus (Asteraceae). Natural Product Communications , 2009, 4 (10), pp.1357 - 1362. ⟨hal-03247444⟩
- Accès au bibtex
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Poster communications
- ref_biblio
- Ghislain Tsague Kenfack, Séverine Derbré, Marylène Dias, Suresh Babu, Kamal Elouarzaki, et al.. New self-assembled monolayers for DIAMS mass spectrometry. "titre manquant", 2009, Dublin, Ireland. 2009. ⟨hal-03247633⟩
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2008
Journal articles
- ref_biblio
- Jean-Jacques Helesbeux, Damien Peyronnet, Mehdi Labaied, Philippe Grellier, François Frappier, et al.. Synthesis and Antimalarial Activity of Some New 1,2-Dioxolane Derivatives. Journal of Enzyme Inhibition and Medicinal Chemistry, 2008, 17 (6), pp.431-437. ⟨10.1080/1475636021000005677⟩. ⟨mnhn-02867489⟩
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- ref_biblio
- Benoit Pinel, Anne Landreau, Joëlle Dubois, G. Au Do, F de La Poype, et al.. Purification hemisynthesis of xanthatin derivates and in vitro evaluation of their activity towards farnesyltransferase (PFTase). Planta Medica, 2008, 74 (9), Non spécifié. ⟨10.1055/s-0028-1084784⟩. ⟨hal-03247509⟩
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- ref_biblio
- Marine Le Moigne, Eric Dufour, Dominique Bertrand, Chantal Maury, Denis Seraphin, et al.. Front face fluorescence spectroscopy and visible spectroscopy coupled with chemometrics have the potential to characterise ripening of Cabernet Franc grapes. Analytica Chimica Acta, 2008, 621 (1), pp.8 - 18. ⟨10.1016/j.aca.2007.09.054⟩. ⟨hal-03247446⟩
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- ref_biblio
- Francis Chevreuil, Anne Landreau, Denis Seraphin, Gérald Larcher, Jean-Philippe Bouchara, et al.. Synthesis of new 1- 2-azido-2-(2,4-dichlorophenyl)ethyl -1H/-imidazoles and in vitro evaluation of their antifungal activity. Journal of Enzyme Inhibition and Medicinal Chemistry, 2008, 23 (5), pp.617 - 622. ⟨10.1080/14756360802205133⟩. ⟨hal-03247515⟩
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Conference papers
- ref_biblio
- M. Bounichou, Lionel Sanguinet, Kamal Elouarzaki, Olivier Alévêque, Marylène Dias, et al.. Desorption/ionization on self-assembled monolayer surfaces (DIAMS): a new matrix-free laser desorption/ionization promising for the analysis of vegetal extracts. 7th Joint Meeting of GA, AFERP, ASP, PSE & SIF, 2008, Athènes, Greece. pp.093, ⟨10.1055/s-0028-1084549⟩. ⟨hal-03247635⟩
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2007
Journal articles
- ref_biblio
- Imad Raad, Anne-Emmanuelle Hay, Joumaa Merza, Nicole Darbour, Anne-Marie Le Ray, et al.. Evaluation of natural phenolic compounds from Clusiaceae as P-glycoprotein inhibitors. Electronic Journal of Natural Substances, 2007, 2, pp.5-11. ⟨hal-02958008⟩
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2002
Journal articles
- ref_biblio
- Cécile Morel, Anne-Emmanuelle Hay, Marc Litaudon, Thierry Sévenet, Denis Séraphin, et al.. Thirteen New Xanthone Derivatives from Calophyllum caledonicum (Clusiaceae). Molecules, 2002, 7 (1), pp.38-50. ⟨10.3390/70100038⟩. ⟨hal-03815281⟩
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