2026

Journal articles

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Guillaume Chesneau, Alba Noel, Dimitri Bréard, Alice Boulanger, Martial Briand, et al.. Lactuchelins represent lipopeptide siderophores produced by Pseudomonas lactucae that inhibit Xanthomonas campestris. The International Society of Microbiologial Ecology Journal, 2026, 20 (1), ⟨10.1093/ismejo/wrag003⟩. ⟨hal-05529897⟩

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2025

Journal articles

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Jerome Monroe Bernardino, Elza Neau, Joséphine Kocuiba, Maïwenn Gadras, Amandine Rigaud, et al.. Transformation of Alternaria dauci demonstrates the involvement of two polyketide synthase genes in aldaulactone production and fungal pathogenicity. Scientific Reports, 2025, 15 (1), pp.34418. ⟨10.1038/s41598-025-17441-z⟩. ⟨hal-05409792⟩

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Dimitri Bréard, Thomas Charpentier, Anne-Marie Le Ray, Nadège Blon, Nelly Bataillé-Simoneau, et al.. Chemical constituents from the latex of Garcinia parvifolia and their anti-Unfolded Protein Response activity. Phytochemistry, 2025, pp.114522. ⟨10.1016/j.phytochem.2025.114522⟩. ⟨hal-05051921⟩

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Pierre Bouillon, Etienne Belin, Anne-Laure Fanciullino, Sandrine Balzergue, Sylvain Hanteville, et al.. Fade into you: genetic control of pigmentation patterns in red-flesh apple (Malus domestica). Frontiers in Plant Science, 2025, 15, pp.1462545. ⟨10.3389/fpls.2024.1462545⟩. ⟨hal-05081217⟩

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Vincent Paillé, Joohee Park, Bertrand Toutain, Jennifer Bourreau, Pierre Fontanaud, et al.. Adaptive remodeling of rat adrenomedullary stimulus-secretion coupling in a chronic hypertensive environment. Cellular and Molecular Life Sciences, 2025, 82 (1), pp.31. ⟨10.1007/s00018-024-05524-5⟩. ⟨hal-04867268⟩

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Preprints, Working Papers, ...

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Guillaume Chesneau, Alba Noel, Dimitri Bréard, Alice Boulanger, Martial Briand, et al.. Lactuchelins: New lipopeptide siderophores from Pseudomonas lactucae inhibit Xanthomonas campestris pv. campestris 8004. 2025. ⟨hal-05293171⟩

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2024

Journal articles

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Manon Meunier, Dimitri Bréard, Séverine Boisard, Patricia Blanchard, Marc Litaudon, et al.. Looking for Actives in the Haystack: Merging HRMS 2 -Based Molecular Networking, Chemometrics, and 13 C NMR-Based Dereplication Approaches. Journal of Natural Products, 2024, 87 (10), pp.2398-2407. ⟨10.1021/acs.jnatprod.4c00647⟩. ⟨hal-04834590⟩

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Manon Meunier, Dimitri Bréard, Séverine Boisard, Patricia Blanchard, Marc Litaudon, et al.. Looking for Actives in the Haystack: Merging HRMS 2 -Based Molecular Networking, Chemometrics, and 13 C NMR-Based Dereplication Approaches. Journal of Natural Products, 2024, ⟨10.1021/acs.jnatprod.4c00647⟩. ⟨hal-04713301⟩

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Pierre Bouillon, Anne-Laure Fanciullino, Etienne Belin, Dimitri Bréard, Séverine Boisard, et al.. Image analysis and polyphenol profiling unveil red-flesh apple phenotype complexity. Plant Methods, 2024, 20 (1), pp.71. ⟨10.1186/s13007-024-01196-1⟩. ⟨hal-04615546⟩

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Marine Chambaud, Anne-Marie Le Ray, Racha Hamzi, Thomas Charpentier, Nadège Blon, et al.. Xanthone Inhibitors of Unfolded Protein Response Isolated from Calophyllum caledonicum. Journal of Natural Products, 2024, 87 (6), pp.1628-1634. ⟨10.1021/acs.jnatprod.4c00328⟩. ⟨hal-04611532⟩

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Conference papers

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Manon Meunier, Martina Haack, Dania Awad, Thomas Brück, Khalijah Awang, et al.. Matrix free laser desorption ion mobility mass spectrometry in chemometrics: A new approach to the rapid identification of activity markers in complex mixtures of natural products. International Congress on Natural Products Research (ICNPR2024), PSE; GA; ASP; AFERP; The Japanese Society of Pharmacognosy; The Korean Society of Pharmacognosy; Societa Italiana Di Fitochimica, Jul 2024, Krakow, Poland. pp.103800, ⟨10.1016/j.phytol.2025.103800⟩. ⟨hal-05415507⟩

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Séverine Derbré, Manon Meunier, Antoine Bruguière, Dimitri Bréard, Séverine Boisard, et al.. Pharmacognosy faces new challenges: proposals to combine chemometrics and annotations based on mass spectrometry and NMR for more accurate and faster identification of bioactive natural products in complex matrices. International Congress on Natural Products Research (ICNPR2024), Jul 2024, Krakow, Poland. pp.103076, ⟨10.1016/j.phytol.2025.103076⟩. ⟨hal-05415514⟩

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2023

Journal articles

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François Azonwade, Balthazar B Mabanza‐banza, Anne‐marie Le Ray, Dimitri Bréard, Patricia Blanchard, et al.. Chemodiversity of propolis samples collected in various areas of Benin and Congo: Chromatographic profiling and chemical characterization guided by ¹³C NMR dereplication. Phytochemical Analysis, 2023, 34 (4), pp.461 - 475. ⟨10.1002/pca.3227⟩. ⟨hal-04214170⟩

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Manon Meunier, Dimitri Bréard, Khalijah Awang, Séverine Boisard, David Guilet, et al.. Matrix free laser desorption ionization assisted by 13C NMR dereplication: A complementary approach to LC-MS2 based chemometrics. Talanta, 2023, 253, pp.123998. ⟨10.1016/j.talanta.2022.123998⟩. ⟨hal-04053658⟩

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Lynda Kheloul, Sylvia Anton, Dimitri Bréard, Abdellah Kellouche. Fumigant toxicity of some essential oils and eucalyptol on different life stages of Tribolium confusum (Coleoptera: Tenebrionidae). Botany Letters, 2023, 170 (1), pp.3-14. ⟨10.1080/23818107.2021.1982767⟩. ⟨hal-03421096⟩

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Preprints, Working Papers, ...

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Vincent Paillé, Joohee Park, Bertrand Toutain, Jennifer Bourreau, Pierre Fontanaud, et al.. Adaptive remodeling of rat adrenomedullary stimulus-secretion coupling in response to a chronic hypertensive environment. 2023. ⟨hal-04330765⟩

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2022

Journal articles

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Salemon Akpa Agnès, Timothée Okpekon, Yvette Affoué Kouadio, Adrien Jagora, Dimitri Bréard, et al.. Implementation of a MS/MS database for isoquinoline alkaloids and other annonaceous metabolites. Scientific Data , 2022, 9 (270), pp.1-8. ⟨10.1038/s41597-022-01345-y⟩. ⟨hal-03783707⟩

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Jacinthe Frangieh, Claire Legendre, Dimitri Bréard, Pascal Richomme, Daniel Henrion, et al.. Oxostephanine, Thalmiculine, and Thaliphyline—Three Isoquinoleine Alkaloids That Inhibit L-Type Voltage-Gated Ca2+ Channels. Future Pharmacology, 2022, 2 (3), pp.238-255. ⟨10.3390/futurepharmacol2030016⟩. ⟨hal-03783742⟩

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Quentin Coquerel, Claire Legendre, Jacinthe Frangieh, Stephan Waard, Jérôme Montnach, et al.. Screening an In-House Isoquinoline Alkaloids Library for New Blockers of Voltage-Gated Na+ Channels Using Voltage Sensor Fluorescent Probes: Hits and Biases. Molecules, 2022, This article belongs to the Special Issue Medicinal Chemistry in Europe III, 27 (13), pp.4133. ⟨10.3390/molecules27134133⟩. ⟨hal-03783732⟩

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Dimitri Bréard, Thibault Barrit, Daniel Sochard, Sophie Aligon, Elisabeth Planchet, et al.. Development of a quantification method for routine analysis of glucosinolates and camalexin in brassicaceous small-sized samples by simultaneous extraction prior to liquid chromatography determination. Journal of Chromatography B - Analytical Technologies in the Biomedical and Life Sciences, 2022, 1205, pp.123348. ⟨10.1016/j.jchromb.2022.123348⟩. ⟨hal-03708527⟩

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Thomas Charpentier, Séverine Boisard, Anne-Marie Le Ray, Dimitri Bréard, Amélie Chabrier, et al.. A Descriptive Chemical Composition of Concentrated Bud Macerates through an Optimized SPE-HPLC-UV-MS2 Method—Application to Alnus glutinosa, Ribes nigrum, Rosa canina, Rosmarinus officinalis and Tilia tomentosa. Plants, 2022, 11 (2), pp.144. ⟨10.3390/plants11020144⟩. ⟨hal-03783689⟩

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2021

Journal articles

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Quentin Coquerel, Fabien Démares, Werner J Geldenhuys, Anne-Marie Le Ray, Dimitri Bréard, et al.. Toxicity and mode of action of the aporphine plant alkaloid liriodenine on the insect GABA receptor. Toxicon, 2021, 201, pp.141-147. ⟨10.1016/j.toxicon.2021.08.019⟩. ⟨hal-04856157⟩

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Konstantin Neukirch, Khaled Alsabil, Chau-Phi Dinh, Rossella Bilancia, Martin Raasch, et al.. Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor that Limits Inflammation. Journal of Medicinal Chemistry, 2021, 64 (15), pp.11496-11526. ⟨10.1021/acs.jmedchem.1c00806⟩. ⟨hal-03783673⟩

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Cesar Auguste Badji, Jean Dorland, Lynda Kheloul, Dimitri Bréard, Pascal Richomme, et al.. Behavioral and Antennal Responses of Tribolium confusum to Varronia globosa Essential Oil and Its Main Constituents: Perspective for Their Use as Repellent. Molecules, 2021, 26 (15), pp.4393. ⟨10.3390/molecules26154393⟩. ⟨hal-03407405⟩

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Antoine Bruguière, Séverine Derbré, Dimitri Bréard, Félix Tomi, Jean-Marc Nuzillard, et al.. 13C NMR Dereplication Using MixONat Software: A Practical Guide to Decipher Natural Products Mixtures. Planta Medica, 2021, ⟨10.1055/a-1470-0446⟩. ⟨hal-03220850⟩

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2020

Journal articles

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Antoine Bruguière, Séverine Derbré, Joël Dietsch, Jules Leguy, Valentine Rahier, et al.. MixONat, a Software for the Dereplication of Mixtures Based on 13 C NMR Spectroscopy. Analytical Chemistry, 2020, 92 (13), pp.8793-8801. ⟨10.1021/acs.analchem.0c00193⟩. ⟨hal-03783604⟩

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2019

Journal articles

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Lynda Kheloul, Abdellah Kellouche, Dimitri Bréard, Marie Gay, Christophe Gadenne, et al.. Trade‐off between attraction to aggregation pheromones and repellent effects of spike lavender essential oil and its main constituent linalool in the flour beetle Tribolium confusum. Entomologia Experimentalis et Applicata, 2019, 167 (9), pp.826-834. ⟨10.1111/eea.12831⟩. ⟨hal-02617828⟩

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Jérémie Babonneau, Dimitri Bréard, Marie-Line Reynaert, Estelle Marion, David Guilet, et al.. Mycolactone as Analgesic: Subcutaneous Bioavailability Parameters. Frontiers in Pharmacology, 2019, 10, pp.378. ⟨10.3389/fphar.2019.00378⟩. ⟨inserm-02100552⟩

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Alexander Fox Ramos, Pierre Le Pogam, Charlotte Fox Alcover, Elvis Otogo N’nang, Gaëla Cauchie, et al.. Collected mass spectrometry data on monoterpene indole alkaloids from natural product chemistry research. Scientific Data , 2019, 6 (1), pp.15. ⟨10.1038/s41597-019-0028-3⟩. ⟨hal-05521960⟩

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E. Ramos, Pierre Le Pogam, Charlotte Fox Alcover, Elvis Otogo N'Nang, Gaëla Cauchie, et al.. Collected mass spectrometry data on monoterpene indole alkaloids from natural product chemistry research. Scientific Data , 2019, 6 (15), pp.1-6. ⟨10.1038/s41597-019-0028-3⟩. ⟨hal-02861053⟩

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Conference papers

ref_biblio

Séverine Derbré, Antoine Bruguière, Joël Dietsch, J. Leguy, V Rahier, et al.. MixONat: Assistance aux analyses déréplicatives par RMN-13C. Journée Scientifique Biogenouest « Du phénome au métabolome », Oct 2019, Angers, France. ⟨hal-02871151⟩

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Quentin Coquerel, Fabien Démares, Anne-Marie Le Ray, Dimitri Bréard, Pascal Richomme, et al.. Liriodenine, a natural plant alkaloid, as a tool to explore new targets for mosquitocidal activity. ACS Meeting, Aug 2019, San Diego, United States. ⟨hal-03023176⟩

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2018

Journal articles

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Andreas Schinkovitz, Pierre Le Pogam, Séverine Derbré, Emilie Vessieres, Patricia Blanchard, et al.. Secondary metabolites from lichen as potent inhibitors of advanced glycation end products and vasodilative agents. Fitoterapia, 2018, 131, pp.182-188. ⟨10.1016/j.fitote.2018.10.015⟩. ⟨hal-01903310⟩

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Dimitri Bréard, Guillaume Viault, Marie-Charlotte Mezier, Sylvain Pagie, Antoine Bruguière, et al.. Additional Insights into Hypericum perforatum Content: Isolation, Total Synthesis, and Absolute Configuration of Hyperbiphenyls A and B from Immunomodulatory Root Extracts. Journal of Natural Products, 2018, 81 (8), pp.1850-1859. ⟨10.1021/acs.jnatprod.8b00325⟩. ⟨inserm-02157665⟩

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Poster communications

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Guillaume Viault, Dimitri Bréard, Chau-Phi Dinh, Blon Nadège, Antoine Bruguière, et al.. Xanthone derivatives from NPs library as potential UPR inhibitors for alternative crop protection: Molecular modelling and biological activity. 30th International Symposium on the Chemistry of Natural Products, Nov 2018, Athens, Greece. ⟨hal-02861017⟩

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Joël Dietsch, Antoine Bruguière, Séverine Derbré, Dimitri Bréard, Sorphon Suor-Cherer, et al.. 13C-NMR dereplication of complex mixtures using a custom algorithm: application to a Garcinia mangostana fruit peel extract. 3rd AFERP & STOLON International Symposium, Jul 2018, Rennes, France. . ⟨hal-02521260⟩

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Guillaume Viault, Sorphon Suor-Cherer, Dimitri Bréard, Chau-Phi Dinh, Blon Nadège, et al.. Extraction and purification of antifungal xanthones from Garcinia mangostana (Clusiaceae). 3ème Symposium International AFERP-STOLON, Jul 2018, Rennes, France. ⟨hal-02795479⟩

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2017

Journal articles

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Frédéric de Nardi, Claudie Lefort, Dimitri Bréard, Pascal Richomme, Christian Legros, et al.. Monitoring the Secretory Behavior of the Rat Adrenal Medulla by High-Performance Liquid Chromatography-Based Catecholamine Assay from Slice Supernatants. Frontiers in Endocrinology, 2017, 8, pp.248. ⟨10.3389/fendo.2017.00248⟩. ⟨inserm-01597318⟩

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Poster communications

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Dimitri Bréard, Guillaume Viault, Antoine Bruguière, Béatrice Charreau, Pascal Richomme, et al.. Total synthesis and determination of the absolute configuration of Hyperbiphenyl A and B, isolated from the roots of Hypericum perforatum. 5th AFERP International Conference "Pharmacognosy from here and there", Jul 2017, Angers, France. . ⟨hal-02521277⟩

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Z. Benbelkacem, Anne-Marie Le Ray, Antoine Bruguière, Sorphon Suor-Cherer, Dimitri Bréard, et al.. Part II: Identifying natural products (NPs) as potential UPR inhibitors for crop protection. 5th AFERP International Conference "Pharmacognosy from here and there", Jul 2017, Angers, France. . ⟨hal-02516597⟩

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2016

Conference papers

ref_biblio

Quentin Coquerel, Anne-Marie Le Ray, Charifat Saïd-Hassane, César Mattei, Nathalie C. Guérineau, et al.. Voltage-Sensor Probes as efficient tools to screen for new modulators of voltage-gated sodium channels. 22nd Meeting of the French Society of Toxinology (SFET). "Toxins: New Targets and New Functions", Dec 2016, Paris, France. pp.72, ⟨10.1016/j.toxicon.2016.01.004⟩. ⟨hal-03023103⟩

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Poster communications

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Antoine Bruguière, Anne-Marie Le Ray, Dimitri Bréard, Nadège Blon, Nelly Bataillé-Simoneau, et al.. Part I: Identifying Natural Products (NPs) as potential UPR inhibitors for crop protection. 9th joint Natural Products Conference, Jul 2016, Copenhague, Denmark. Georg Thieme Verlag, Planta medica, 82 (S 01), pp.S1-S381, 2016, ⟨10.1055/s-0036-1596783⟩. ⟨hal-02516441⟩

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2015

Poster communications

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Quentin Coquerel, Anne-Marie Le Ray, César Mattei, Nathalie C. Guérineau, Dimitri Bréard, et al.. Screening an in house alkaloids library using Voltage-Sensor Probes for new modulators of voltage-gated sodium channels. 26th Ion Channel Meeting, Sep 2015, Sète, France. . ⟨hal-02521271⟩

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Nina Corlay, Aurore Michaud, Aïssata Camara, Marie-Charlotte Mezier, Bach Tai Dang, et al.. Chemically engineered extracts of Hypericum perforatum (St John’s wort) as sources of bioactive compounds to prevent endothelial dysfunction. 2ème Symposium International AFERP-STOLON "Biodiversité et substances naturelles", Jul 2015, Lyon, France. ⟨hal-02521279⟩

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2014

Journal articles

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Joseph Magadula, Pax Masimba, Rose Tarimo, Zaituni Msengwa, Zakariah H Mbwambo, et al.. Mammea-type coumarins from Mammea usambarensis Verdc.. Biochemical Systematics and Ecology, 2014, 56, pp.65-67. ⟨10.1016/j.bse.2014.05.004⟩. ⟨hal-03287473⟩

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Conference papers

ref_biblio

Quentin Coquerel, Anne-Marie Le Ray, Charifat Saïd-Hassane, César Mattei, Nathalie C. Guérineau, et al.. Voltage Sensor Probes as an efficient tool to screen for new modulators of voltage-gated sodium channels. 22nd Meeting of the French Society of Toxinology (SFET). "Toxins: New Targets and New Functions, 2014, Paris, France. ⟨hal-03247960⟩

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Poster communications

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Isabelle Baglin, Lizeth Bodero, Séverine Derbré, Patricia Blanchard, Dimitri Bréard, et al.. Phloroglucinol : a simple core for new anti-AGEs derivatives - synthesis, anti-AGEs activity and RSA. 22e GP2A meeting of the "Groupement des Pharmacochimistes de l'Arc Atlantique", 2014, Nantes, France. 2014. ⟨hal-03247874⟩

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Dimitri Bréard, Séverine Derbré, Patricia Blanchard, Khalijah Awang, Hamid Hadib, et al.. Anti-AGE bioguided fractionation and dereplication study of Calophyllum wallichianum stem bark. 10e reuniόn internacional de investigaciόn en productos naturales, 2014, Merida, Mexico. 2014. ⟨hal-03247879⟩

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Charifat Saïd-Hassane, Quentin Coquerel, Anne-Marie Le Ray, Dimitri Bréard, Benjamin Siegler, et al.. Voltage Sensor Probes (VSPs) as an Efficient Tool to Screen for Inhibitors of Voltage-Gated Sodium Channels. Natural Products and Drug Discovery-Future Perspectives, 2014, Vienne, Austria. 2014. ⟨hal-03247952⟩

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