- titre
- Transgenerational effects of gamma radiation dose and dose rate on Drosophila flies irradiated at an early embryonal stage
- auteur
- Traimate Sangsuwan, Mattias Mannervik, Siamak Haghdoost
- article
- Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 2022, 881, pp.503523. ⟨10.1016/j.mrgentox.2022.503523⟩
- titre
- CYCLHAD: A French Facility Dedicated for Research and Treatment in Hadrontherapy
- auteur
- François Chevalier, P. Lesueur, G. Gaubert
- article
- Nuclear Physics News, 2022, 32 (2), pp.27-31. ⟨10.1080/10619127.2022.2063002⟩
- titre
- A systems radiation biology approach to unravel the role of chronic low-dose-rate gamma-irradiation in inducing premature senescence in endothelial cells
- auteur
- Gabriele Babini, Giorgio Baiocco, Sofia Barbieri, Jacopo Morini, Traimate Sangsuwan, Siamak Haghdoost, Ramesh Yentrapalli, Omid Azimzadeh, Charlotte Rombouts, An Aerts, Roel Quintens, Teni Ebrahimian, Mohammed Abderrafi Benotmane, Raghda Ramadan, Sarah Baatout, Soile Tapio, Mats Harms-Ringdahl, Andrea Ottolenghi
- article
- PLoS ONE, 2022, 17 (3), pp.e0265281. ⟨10.1371/journal.pone.0265281⟩
- titre
- Radioresistance of Non-Small Cell Lung Cancers and Therapeutic Perspectives
- auteur
- Mathieu Césaire, Juliette Montanari, Hubert Curcio, Delphine Lerouge, Radj Gervais, Pierre Demontrond, Jacques Balosso, François Chevalier
- article
- Cancers, 2022, 14 (12), pp.2829. ⟨10.3390/cancers14122829⟩
- titre
- Label-Free Direct Mass Spectrometry Analysis of the Bystander Effects Induced in Chondrocytes by Chondrosarcoma Cells Irradiated with X-rays and Carbon Ions
- auteur
- Antoine Gilbert, Valentin Payet, Benoît Bernay, Elisabeth Chartier-Garcia, Isabelle Testard, Serge M. Candéias, François Chevalier
- article
- Frontiers in Bioscience-Landmark, 2022, 27 (9), pp.277. ⟨10.31083/j.fbl2709277⟩
- titre
- Role of KRAS mutation on NSCLC resistance to X-rays and protons
- auteur
- Juliette Montanari, Mathieu Césaire, Antoine Gilbert, François Chevalier
- article
- ERRS 2022 - 47th Annual Meeting of the European Radiation Research Society, Sep 2022, Catania, Italy.
- titre
- Analysis of ionizing radiation induced effects in radioresistant tumours and bystander normal cells
- auteur
- M Tudor, A Gilbert, M Temelie, A Dinischiotu, François Chevalier, D Savu
- article
- 46th FEBS Congress, Jul 2022, Lisbon, Portugal
- titre
- Impact de l'hadronthérapie par ions carbone et protons sur les cellules souches cancéreuses de chondrosarcome en hypoxie
- auteur
- Antoine Gilbert, Juliette Montanari, Kévin Commenchail, Marilyne Guillamin, Samuel Valable, François Chevalier
- article
- 14éme journée scientifique de la cancéropôle Nord-Ouest, May 2022, Deauville, France
- titre
- Avoidance or adaptation of radiotherapy in patients with cancer with Li-Fraumeni and heritable TP53-related cancer syndromes
- auteur
- Juliette Thariat, François Chevalier, Daniel Orbach, Luc Ollivier, Pierre-Yves Marcy, Nadege Corradini, Arnaud Beddok, Nicolas Foray, Gaelle Bougeard
- article
- Lancet Oncology, 2021, 22 (12), pp.e562-e574. ⟨10.1016/S1470-2045(21)00425-3⟩
- titre
- Effect of dose and dose rate of gamma irradiation on the formation of micronuclei in bone marrow cells isolated from whole‐body‐irradiated mice
- auteur
- Paulo Roberto d'Auria Vieira de Godoy, Ayumi Nakamura, Ali Pour Khavari, Traimate Sangsuwan, Siamak Haghdoost
- article
- Environmental and Molecular Mutagenesis, 2021, 62 (7), pp.422-427. ⟨10.1002/em.22453⟩
- titre
- A Proteomic Study Suggests Stress Granules as New Potential Actors in Radiation-Induced Bystander Effects
- auteur
- Mihaela Tudor, Antoine Gilbert, Charlotte Lepleux, Mihaela Temelie, Sonia Hem, Jean Armengaud, Emilie Brotin, Siamak Haghdoost, Diana Savu, François Chevalier
- article
- International Journal of Molecular Sciences, 2021, 22 (15), pp.7957. ⟨10.3390/ijms22157957⟩
- titre
- Exposure to low to moderate doses of ionizing radiation induces a reduction of pro-inflammatory Ly6Chigh monocytes and a U-curved response of T cells in ApoE -/- mice
- auteur
- Nicolas Rey, Talin Ebrahimian, Celine Gloaguen, Dimitri Kerezelidze, Victor Magneron, Alice Bontemps, Christelle Demarquay, Gunilla Olsson, Siamak Haghdoost, Stephanie Lehoux, Teni Ebrahimian Chiusa
- article
- Dose-Response, 2021, 19 (2), pp.1-9. ⟨10.1177/15593258211016237⟩
- titre
- Impact of Hypoxia and Hadrontherapy on Radioresistant Chondrosarcoma Cancer Stem Cells
- auteur
- Antoine Gilbert, Julie Laurence, Marilyne Guillamin, Siamak Haghdoost, Samuel Valable, François Chevalier
- article
- Proceeding of the ERRS 2021, Nov 2021, CAEN, France. pp.93
- titre
- Presentation of the CIRIL / radiation biology platform dedicated for experiments with the GANIL facility
- auteur
- Chevalier François, Violaine Vizcaino, Jean-Christophe Poully, Alain Mery, Jimmy Rangama
- article
- ERRS 2021, Nov 2021, CAEN, France
- titre
- Sensitization of chondrosarcoma cells with PARP inhibitor and impact on cancer stem cells
- auteur
- Mathieu Césaire, Antoine Gilbert, Julie Laurence, Nicolas Elie, Florence Giffard, Siamak Haghdoost, Louis-Bastien Weiswald, François Chevalier
- article
- ERRS 2021, Nov 2021, CAEN, France
- titre
- A multimodal treatment of carbon ions irradiation, miRNA-34 and mTOR inhibitor specifically control high-grade chondrosarcoma cancer stem cells
- auteur
- Guillaume Vares, Vidhula Ahire, Shigeaki Sunada, Eun Ho Kim, Sei Sai, François Chevalier, Paul-Henri Romeo, Tadashi Yamamoto, Tetsuo Nakajima, Yannick Saintigny
- article
- Radiotherapy & Oncology, 2020, 150, pp.253-261. ⟨10.1016/j.radonc.2020.07.034⟩
- titre
- Targeting NRF2, Regulator of Antioxidant System, to Sensitize Glioblastoma Neurosphere Cells to Radiation-Induced Oxidative Stress
- auteur
- Paulo Godoy, Ali Pour Khavari, Marzia Rizzo, Elza Sakamoto-Hojo, Siamak Haghdoost
- article
- Oxidative Medicine and Cellular Longevity, 2020, 2020, pp.1-17. ⟨10.1155/2020/2534643⟩
- titre
- Molecular Profiling for Predictors of Radiosensitivity in Patients with Breast or Head-and-Neck Cancer
- auteur
- Kimi Drobin, Michal Marczyk, Martin Halle, Daniel Danielsson, Anna Papiez, Traimate Sangsuwan, Annika Bendes, Mun-Gwan Hong, Ulrika Qundos, Mats Harms-Ringdahl, Peter Wersäll, Joanna Polanska, Jochen Schwenk, Siamak Haghdoost
- article
- Cancers, 2020, 12 (3), pp.753. ⟨10.3390/cancers12030753⟩
- titre
- Establishing mechanisms affecting the individual response to ionising radiation
- auteur
- Dietrich Averbeck, Serge M. Candéias, Sudhir Chandna, Nicolas Foray, Anna Friedl, Siamak Haghdoost, Pénélope Jeggo, Katalin Lumniczky, François Paris, Roel Quintens, Laure Sabatier
- article
- International Journal of Radiation Biology, 2020, 96 (3), pp.297-323. ⟨10.1080/09553002.2019.1704908⟩
- titre
- Effects of Tomato Juice Intake on Salivary 8-Oxo-dG Levels as Oxidative Stress Biomarker after Extensive Physical Exercise
- auteur
- Ali Pour Khavari, Siamak Haghdoost
- article
- Oxidative Medicine and Cellular Longevity, 2020, 2020, pp.1-6. ⟨10.1155/2020/8948723⟩
- titre
- Hadrontherapy Interactions in Molecular and Cellular Biology
- auteur
- Juliette Thariat, Samuel Valable, Carine Laurent, Siamak Haghdoost, Elodie A. Pérès, Myriam Bernaudin, François Sichel, Paul Lesueur, Mathieu Césaire, Edwige Petit, Aurélie Ferré, Yannick Saintigny, Sven Skog, Mihaela Tudor, Michael Gérard, Sébastien Thureau, Jean-Louis Habrand, Jacques Balosso, François Chevalier
- article
- International Journal of Molecular Sciences, 2020, 21 (1), pp.133. ⟨10.3390/ijms21010133⟩
- titre
- Counteracting Radio-Resistance Using the Optimization of Radiotherapy
- auteur
- François Chevalier
- article
- International Journal of Molecular Sciences, 2020, 21 (5), pp.1767. ⟨10.3390/ijms21051767⟩
- titre
- Proteomic analysis of bystander effects in chondrosarcoma cells
- auteur
- Antoine Gilbert, Mihaela Tudor, Charlotte Lepleux, V. Rofidal, Sonia Hem, Christine Almunia, J. Armengaud, Emilie Brotin, Siamak Haghdoost, Diana Savu, François Chevalier
- article
- 45th Annual Meeting of the European Radiation Research Society, Sep 2020, Lund, Sweden. , pp.123
- titre
- High LET Radiation Overcomes In Vitro Resistance to X-Rays of Chondrosarcoma Cell Lines
- auteur
- François Chevalier, Dounia Houria Hamdi, Charlotte Lepleux, Mihaela Temelie, Anaïs Nicol, Jean Baptiste Austry, Paul Lesueur, Guillaume Vares, Diana Savu, Tetsuo Nakajima, Yannick Saintigny
- article
- Technology in Cancer Research and Treatment, 2019, 18, pp.153303381987130. ⟨10.1177/1533033819871309⟩
- titre
- Sensitization of chondrosarcoma cells with PARP inhibitor and high-LET radiation
- auteur
- Mathieu Césaire, Utpal Ghosh, Jean-Baptiste Austry, Etienne Müller, Francesco Paolo Cammarata, Marilyne Guillamin, Massimo Caruso, Laurent Castéra, Giada Petringa, Giuseppe Antonio Pablo Cirrone, François Chevalier
- article
- Journal of Bone Oncology, 2019, 17, pp.100246. ⟨10.1016/j.jbo.2019.100246⟩
- titre
- Bystander effectors of chondrosarcoma cells irradiated at different LET impair proliferation of chondrocytes
- auteur
- Charlotte Lepleux, Aurélie Marie-Brasset, Mihaela Temelie, Marion Boulanger, Émilie Brotin, Mary B Goldring, Christophe Hirtz, Guillaume Varès, Tetsuo Nakajima, Yannick Saintigny, Diana Savu, François Chevalier
- article
- Journal of Cell Communication and Signaling, 2019, 13 (3), pp.343-356. ⟨10.1007/s12079-019-00515-9⟩
- titre
- P47. Proteomic analysis of the Radiation-Induced Bystander Effects between low-dose irradiated Chondrosarcoma cells and Bystander Chondrocytes
- auteur
- Charlotte Lepleux, Valerie Rofidal, Sonia Hem, Christine Almunia, J. Armengaud, François Chevalier
- article
- 4th European Radiation Protection Week, Oct 2019, Stockholm, Sweden
- titre
- P23 - Bystander effectors of chondrosarcoma cells irradiated at different LET impair proliferation of chondrocytes
- auteur
- Charlotte Lepleux, Diana Savu, François Chevalier
- article
- 16th International Congress of Radiation Research, Aug 2019, Manchester, United Kingdom
- titre
- Proteomic analysis of the Radiation-Induced Bystander Effects
- auteur
- Charlotte Lepleux, François Chevalier
- article
- ENLIGHT Annual Meeting and Training 2019, Jul 2019, Caen, France
- titre
- Sensitization of chondrosarcoma cells with PARP inhibitor and high-LET radiation
- auteur
- Mathieu Césaire, Utpal Ghosh, Jean Baptiste Austry, Francesco Cammarata, Laurent Castera, Giuseppe Antonio Pablo Cirrone, François Chevalier
- article
- ENLIGHT Annual Meeting and Training 2019, Jul 2019, Caen, France
- titre
- Bystander effectors of chondrosarcoma cells irradiated at different LET impair proliferation of chondrocytes
- auteur
- Charlotte Lepleux, Aurélie Marie-Brasset, Emilie Brotin, Tetsuo Nakajima, Diana Savu, François Chevalier
- article
- ENLIGHT Annual Meeting and Training 2019, Jul 2019, Caen, France
- titre
- High LET Radiation Overcomes in vitro Resistance to X-rays of Chondrosarcoma Cell Lines
- auteur
- Dounia Houria Hamdi, Charlotte Lepleux, Agnès Nicolle, Guillaume Varès, Paul Lesueur, François Chevalier
- article
- ENLIGHT Annual Meeting and Training 2019, Jul 2019, Caen, France
- titre
- Radiosensitization Effect of Talazoparib, a Parp Inhibitor, on Glioblastoma Stem Cells Exposed to Low and High Linear Energy Transfer Radiation
- auteur
- Paul Lesueur, François Chevalier, Elias A. El-Habr, Marie-Pierre Junier, Hervé Chneiweiss, Laurent Castéra, Etienne Müller, Dinu Stefan, Yannick Saintigny
- article
- Scientific Reports, 2018, 8, pp.3664. ⟨10.1038/s41598-018-22022-4⟩
- titre
- Combining PARP inhibition, radiation, and immunotherapy: A possible strategy to improve the treatment of cancer?
- auteur
- Mathieu Césaire, Juliette Thariat, Serge M. Candéias, Dinu Stefan, Yannick Saintigny, François Chevalier
- article
- International Journal of Molecular Sciences, 2018, 19 (12), pp.3793. ⟨10.3390/ijms19123793⟩
- titre
- Poly-(ADP-ribose)-polymerase inhibitors as radiosensitizers: a systematic review of pre-clinical and clinical human studies
- auteur
- Paul Lesueur, François Chevalier, Jean-Baptiste Austry, Waisse Waissi, Hélène Burckel, Georges Noel, Jean-Louis Habrand, Yannick Saintigny, Florence Joly
- article
- Oncotarget, 2017, 8 (40), ⟨10.18632/oncotarget.19079⟩
- titre
- Differential pattern of HIF-1α expression in HNSCC cancer stem cells after carbon ion or photon irradiation: one molecular explanation of the oxygen effect
- auteur
- Anne-Sophie Wozny, Alexandra Lauret, Priscillia Battiston-Montagne, Jean-Baptiste Guy, Michael Beuve, Micaela Cunha, Yannick Saintigny, Emilie Blond, Nicolas Magné, Philippe Lalle, Dominique Ardail, Gersende Alphonse, Claire Rodriguez-Lafrasse
- article
- British Journal of Cancer, 2017, 116 (10), pp.1340 - 1349. ⟨10.1038/bjc.2017.100⟩
- titre
- Review of the Mechanisms Involved in the Abscopal Effect and Future Directions with a Focus on Thymic Carcinoma
- auteur
- Paul Lesueur, François Chevalier, Dinu Stefan, Jean-Louis Habrand, Delphine Lerouge, Radj Gervais
- article
- Tumori, 2017, 103 (3), pp.217-222. ⟨10.5301/tj.5000616⟩
- titre
- Translational research in radiobiology in the framework of France HADRON national collaboration
- auteur
- Claire Rodriguez-Lafrasse, Yannick Saintigny, François Chevalier, Myriam Bernaudin, Carine Laurent, Frédéric Pouzoulet, Yolanda Prezado, Frédérique Mégnin-Chanet, Agnès François, Olivier Guipaud, Michaël Beuve, Jacques Balosso
- article
- Translational Cancer Research, 2017, 6 (S5), pp.S795-S806. ⟨10.21037/tcr.2017.06.33⟩
- titre
- A major contribution of the HIF-1α pathway in the oxygen effect
- auteur
- Anne-Sophie Wozny, Gersende Alphonse, Yannick Saintigny, Michaël Beuve, Claire Rodriguez-Lafrasse
- article
- 63rd annual international meeting of Radiation Reaserach Society, Oct 2017, Cancun, Mexico. 2017
- titre
- Role of HIF-1α in the resistance of Cancer Stem Cells to photon and carbon ion irradiations
- auteur
- Anne-Sophie Wozny, Michael Beuve, Yannick Saintigny, Tetsuo Nakajima, Guillaume Vares, Gersende Alphonse, Claire Rodriguez-Lafrasse
- article
- 15th International Wolfsberg Meeting on Molecular Radiation Biology/Oncology, Jun 2017, Ermatingen, Switzerland. 2017
- titre
- Role of HIF-1α in the Resistance of Cancer Stem Cells to Photon and Carbon Ion Irradiations
- auteur
- Anne-Sophie Wozny, Jean-Baptiste Guy, Céline Malésys, Priscillia Battiston-Montagne, Michael Beuve, Yannick Saintigny, Gersende Alphonse, Claire Rodriguez-Lafrasse
- article
- Forum de la Recherche en Cancérologie Auvergne-Rhône-Alpes 2017, Apr 2017, Lyon, France
- titre
- Comparable Senescence Induction in Three-dimensional Human Cartilage Model by Exposure to Therapeutic Doses of X-rays or C-ions
- auteur
- Dounia Hamdi, François Chevalier, Jean-Emmanuel Groetz, Florent Durantel, Jean-Yves Thuret, Carl Mann, Yannick Saintigny
- article
- International Journal of Radiation Oncology, Biology, Physics, 2016, 95 (1), pp.139 - 146. ⟨10.1016/j.ijrobp.2016.02.014⟩
- titre
- Dosimetry for radiobiology experiments at GANIL
- auteur
- Florent Durantel, Emmanuel Balanzat, Amine Cassimi, François Chevalier, Yvette Ngono-Ravache, Toiammou Madi, Jean-Christophe Poully, Jean-Marc Ramillon, Hermann Rothard, Frédéric Ropars, Lucas Schwob, Isabelle Testard, Yannick Saintigny
- article
- Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2016, 816, pp.70 - 77. ⟨10.1016/j.nima.2016.01.052⟩
- titre
- A threshold of endogenous stress is required to engage cellular response to protect against mutagenesis.
- auteur
- Yannick Saintigny, François Chevalier, Anne Bravard, Elodie Dardillac, David Laurent, Sonia Hem, Jordane Dépagne, J Pablo Radicella, Bernard S Lopez
- article
- Scientific Reports, 2016, 6, pp.29412. ⟨10.1038/srep29412⟩
- titre
- A key role of HIF-1α in the radioresistance of Cancer Stem Cells in their hypoxic microenvironment
- auteur
- Anne-Sophie Wozny, Alexandra Lauret, Yannick Saintigny, Priscillia Battiston-Montagne, Michael Beuve, Gersende Alphonse, Claire Rodriguez-Lafrasse
- article
- 42nd Conference on the European radiation research society (ERR 2016), Sep 2016, Amsterdam, Netherlands
- titre
- Essential role of HIF-1α in both resistance to photon and carbon ion exposures and invasiveness of Head and Neck Squamous Cell Carcinoma (HNSCC) cancer stem cells
- auteur
- Anne-Sophie Wozny, Alexandra Lauret, Yannick Saintigny, Priscillia Battiston-Montagne, Michaël Beuve, Gersende Alphonse, Claire Rodriguez-Lafrasse
- article
- Forum de la recherche en cancérologie Rhône-Alpes Auvergne, Mar 2016, Lyon, France
- titre
- In vitro engineering of human 3D chondrosarcoma: a preclinical model relevant for investigations of radiation quality impact
- auteur
- Dounia Hamdi, Sofia Barbieri, François Chevalier, Jean-Emmanuel Groetz, Florence Legendre, Magali Demoor, Philippe Galera, Jean-Louis Lefaix, Yannick Saintigny
- article
- BMC Cancer, 2015, ⟨10.1186/s12885-015-1590-5⟩
- titre
- Differential Radiosensitivity of Uveal Melanoma Cell Lines After X-rays or Carbon Ions Radiation.
- auteur
- A Calipel, A-L Lux, S Guérin, J-L Lefaix, C Laurent, M Bernaudin, F Mouriaux
- article
- Investigative Ophthalmology & Visual Science, 2015, 56 (5), pp.3085-94. ⟨10.1167/iovs.14-15930⟩
- titre
- Radiation-Induced Alterations of Osteogenic and Chondrogenic Differentiation of Human Mesenchymal Stem Cells
- auteur
- Séverine Cruet-Hennequart, Carole Drougard, Georgina Shaw, Florence Legendre, Magali Demoor, Frank Barry, Jean-Louis Lefaix, Philippe Galera
- article
- PLoS ONE, 2015, 10 (4), pp.e0119334. ⟨10.1371/journal.pone.0119334⟩
- titre
- Impact of Therapeutic Irradiation on Healthy Articular Cartilage
- auteur
- Yannick Saintigny, Séverine Cruet-Hennequart, Dounia Houria Hamdi, François Chevalier, Jean-Louis Lefaix
- article
- Radiation Research, 2015, 183 (2), pp.135-146. ⟨10.1667/rr13928.1⟩
- titre
- Proteomic overview and perspectives of the radiation-induced bystander effects
- auteur
- François Chevalier, Dounia Houria Hamdi, Yannick Saintigny, Jean-Louis Lefaix
- article
- Mutation Research/Reviews in Mutation Research, 2015, 763, pp.280-293. ⟨10.1016/j.mrrev.2014.11.008⟩
- titre
- ROLE DU MICROENVIRONNEMENT HYPOXIQUE DANS L’ECHAPPEMENT TUMORAL DES CANCERS EPIDERMOÏDES DE LA TETE ET DU COU EN REPONSE A L’IRRADIATION PHOTONIQUE ET PAR IONS CARBONE
- auteur
- Anne-Sophie Wozny, Alexandra Lauret, Yannick Saintigny, Priscillia Battiston-Montagne, Michael Beuve, Gersende Alphonse, Claire Rodriguez-Lafrasse
- article
- 12ème Colloque International de Radiobiologie Fondamentale et Appliquée - SIRLAF, Nov 2015, Obernai, France
- titre
- Effet Bystander en Radiobiologie et Hadronthérapie
- auteur
- François Chevalier
- article
- Cancer. Paris Saclay, 2015
- titre
- Dramatic Increase in Oxidative Stress in Carbon-Irradiated Normal Human Skin Fibroblasts
- auteur
- Carine Laurent, Alexandre Leduc, Ivannah Pottier, Virginie Prevost, François Sichel, Jean-Louis Lefaix
- article
- PLoS ONE, 2013, 8 (12), pp.e85158. ⟨10.1371/journal.pone.0085158⟩
- titre
- Detection of extracellular 8-oxo-7,8-dihydro-2′-deoxyguanosine as a biomarker of oxidative damage in X-irradiated fibroblast cultures: optimization of analytical procedure
- auteur
- Stéphanie Lagadu, Ivannah Pottier, François Sichel, Carine Laurent, Jean-Louis Lefaix, Virginie Prevost
- article
- Biomarkers, 2010, 15 (8), pp.707-714. ⟨10.3109/1354750X.2010.511269⟩
- titre
- Different Mechanisms of Cell Death in Radiosensitive and Radioresistant P53 Mutated Head and Neck Squamous Cell Carcinoma Cell Lines Exposed to Carbon Ions and X-Rays
- auteur
- M. Maalouf, A. Gersende, A. Colliaux, M. Beuve, S. Trajkovic-Bodennec, P. Battiston-Montagne, I. Testard, O. Chapet, M. Bajard, G. Taucher-Scholz, Clarisse Fournier, C. Rodriguez-Lafrasse
- article
- International Journal of Radiation Oncology, Biology, Physics, 2009, 74, pp.200-209. ⟨10.1016/j.ijrobp.2009.01.012⟩