2024
Journal articles
- titre
- Photodynamic therapy alone or in combination to counteract bacterial infections
- auteur
- Sébastien Clément, Jean-Yves Winum
- article
- Expert Opinion on Therapeutic Patents, 2024, pp.1-14. ⟨10.1080/13543776.2024.2327308⟩
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- titre
- Synthesis and investigation of linear and nonlinear optical properties of an octahedral metalloporphyrin
- auteur
- Muhammad Yaseen, Zahid Farooq, Matloob Ahmad, Muhammad Abdullah Sultan, Muhammad Asam Raza, Jean-Yves Winum, Muhamad Mustafa, Mian Hr. Mahmood, Muhammad Tayyab, Muhammad Adnan Iqbal, Muhammad Shabir Mahr
- article
- Optical Materials, 2024, 149, pp.115092. ⟨10.1016/j.optmat.2024.115092⟩
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- titre
- Boron-containing carbonic anhydrases inhibitors
- auteur
- Simone Giovannuzzi, Anna Nikitjuka, Bruna Rafaela Pereira Resende, Michael Smietana, Alessio Nocentini, Claudiu T Supuran, Jean-Yves Winum
- article
- Bioorganic Chemistry, 2024, 143, pp.106976. ⟨10.1016/j.bioorg.2023.106976⟩
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- titre
- Thiochromenocarbazole imide-based photosensitizers decorated with carbonic anhydrase inhibitors for the targeted treatment of hypoxic tumours
- auteur
- Amina Merabti, Darío Puchán Sánchez, Alessio Nocentini, Lamiaa Ali, Christophe Nguyen, Denis Durand, Kathleen Hamon, Tatiana Ghanem, Philippe Arnoux, Pierre Josse, Céline Frochot, Raivis Zalubovskis, Sébastien Richeter, Magali Gary-Bobo, Claudiu Supuran, Clément Cabanetos, Jean-Yves Winum, Sébastien Clément
- article
- Materials Advances, 2024, ⟨10.1039/D3MA00926B⟩
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Book sections
- titre
- Histidinol dehydrogenase
- auteur
- Jean-Yves Winum
- article
- Metalloenzymes, Elsevier, pp.255-263, 2024, ⟨10.1016/B978-0-12-823974-2.00020-6⟩
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Books
- titre
- Structure des molécules organiques : l'essentiel pour l'étudiant
- auteur
- Perrio Stéphane, Béatrice Roy, Jean-Yves Winum
- article
- Dunod. 2024, 9782100864041
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2023
Journal articles
- titre
- CR322: a Web-Based Board Game for Aiding Students in Reviewing Chemical Reactivity
- auteur
- José Nunes da Silva Júnior, Antonio José Melo Leite Junior, Maria Clara Alexandre, Francisco Serra Oliveira Alexandre, Lucas Lima da Silva, Jean‐Yves Winum
- article
- Journal of Chemical Education, 2023, 100 (12), pp.4866-4871. ⟨10.1021/acs.jchemed.3c00758⟩
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- titre
- Are tumour-associated carbonic anhydrases genuine therapeutic targets for photodynamic therapy?
- auteur
- Amina Merabti, Sébastien Richeter, Claudiu T Supuran, Sébastien Clement, Jean-Yves Winum
- article
- Expert Opinion on Therapeutic Targets, 2023, 27 (9), pp.817-826. ⟨10.1080/14728222.2023.2255380⟩
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- titre
- 6-Substituted Triazolyl Benzoxaboroles as Selective Carbonic Anhydrase Inhibitors: In Silico Design, Synthesis, and X-ray Crystallography
- auteur
- Alessio Nocentini, Alessandro Bonardi, Carla Bazzicalupi, Vincenzo Alterio, Davide Esposito, Simona Maria Monti, Michael Smietana, Giuseppina de Simone, Claudiu Supuran, Paola Gratteri, Jean-Yves Winum
- article
- Journal of Medicinal Chemistry, 2023, 66 (12), pp.8118-8129. ⟨10.1021/acs.jmedchem.3c00433⟩
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- titre
- A combined DFT and molecular docking study on novel tricarbonylrhenium(I) complexes bearing mono- and bivalent benzenesulfonamide scaffolds as human carbonic anhydrase IX and XII inhibitors
- auteur
- Khairedine Kraim, Jean-Yves Winum, Eric Benoist, Achour Seridi, Ourdjini Zeyneb
- article
- Journal of Molecular Structure, 2023, 1282, pp.135211. ⟨10.1016/j.molstruc.2023.135211⟩
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- titre
- Chem’Sc@pe: an Organic Chemistry Learning Digital Escape Game
- auteur
- Béatrice Roy, Stéphan Gasca, Jean-Yves Winum
- article
- Journal of Chemical Education, 2023, 100 (3), pp.1382-1391. ⟨10.1021/acs.jchemed.2c01105⟩
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2022
Journal articles
- titre
- STR120: A Web-Based Board Game for Aiding Students in Review of the Structural Theory of Organic Compounds
- auteur
- José Nunes da Silva Júnior, Jean-Yves Winum, Andrea Basso, Luca Gelati, Lisa Moni, Antonio José Melo Leite Junior, Jair Mafezoli, Dávila Zampieri, Francisco Serra Oliveira Alexandre, Kimberly Benedetti Veja, André Jalles Monteiro
- article
- Journal of Chemical Education, 2022, 99 (9), pp.3315-3322. ⟨10.1021/acs.jchemed.2c00389⟩
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- titre
- Carbonic Anhydrase Inhibitors Featuring a Porphyrin Scaffold: Synthesis, Optical and Biological Properties
- auteur
- Amina Merabti, Maxime Roger, Christophe Nguyen, Alessio Nocentini, Philippe Gerbier, Sébastien Richeter, Magali Gary-Bobo, Claudiu Supuran, Sébastien Clément, Jean‐Yves Winum
- article
- European Journal of Organic Chemistry, 2022, 2022 (21), pp.e202101538. ⟨10.1002/ejoc.202101538⟩
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- titre
- A Virtual Game-Based Tournament to Engage Students in Reviewing Organic Acids and Bases Concepts
- auteur
- José Nunes da Silva Júnior, Dávila Zampieri, Antonio José Melo Leite Junior, Francisco Serra Oliveira Alexandre, Jean-Yves Winum, Andrea Basso, André Jalles Monteiro, Lucas Lima da Silva
- article
- Journal of Chemical Education, 2022, 99 (5), pp.2190-2197. ⟨10.1021/acs.jchemed.1c01220⟩
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- titre
- Addition to “Nomenclature Bets: An Innovative Computer-Based Game to Aid Students in the Study of Nomenclature of Organic Compounds─Version 2.0”
- auteur
- José Nunes da Silva Junior, Mary Anne Sousa Lima, Fátima Miranda Nunes, Antonio José Melo Leite Junior, Francisco Serra Oliveira Alexandre, Djheyson Carlos de Oliveira Assis, Davi Janô Nobre, Jean-Yves Winum, André Jalles Monteiro, Diogo Thomas Ferreira de Lima
- article
- Journal of Chemical Education, 2022, 99 (5), pp.2208-2212. ⟨10.1021/acs.jchemed.2c00167⟩
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- titre
- 1,5‐Benzodiazepines as a platform for the design of carbonic anhydrase inhibitors
- auteur
- Chiraz Ismail, Alessio Nocentini, Claudiu Supuran, Jean‐yves Winum, Rafik Gharbi
- article
- Archiv der Pharmazie / Chemistry in Life Sciences, 2022, 355 (3), pp.2100405. ⟨10.1002/ardp.202100405⟩
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- titre
- The importance of sulfur-containing motifs in drug design and discovery
- auteur
- Muhamad Mustafa, Jean-Yves Winum
- article
- Expert Opinion on Drug Discovery, 2022, 17 (5), pp.501-512. ⟨10.1080/17460441.2022.2044783⟩
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Books
- titre
- Chimie organique expérimentale: L'essentiel pour l'étudiant
- auteur
- Jean-Yves Winum, Perrio Stéphane, Béatrice Roy
- article
- Dunod. 2022, 978-2100836239
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- titre
- Mémo visuel de chimie générale - 2e édition
- auteur
- Isabelle Dumazet-Bonnamour, Jean‐sébastien Filhol, Frédéric Lemoigno, Nathalie Perol, Jean-Yves Winum
- article
- Dunod. 2022, 978-2100840496
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2021
Journal articles
- titre
- Addition to “Stereochemistry Game: Creating and Playing a Fun Board Game To Engage Students in Reviewing Stereochemistry Concepts—The Online Version”
- auteur
- José Nunes da Silva Júnior, Daniel Esdras de Andrade Uchoa, Mary Anne Sousa Lima, André Jalles Monteiro, Antonio José Melo Leite Junior, Jean-Yves Winum, Andrea Basso
- article
- Journal of Chemical Education, 2021, 98 (9), pp.3055-3057. ⟨10.1021/acs.jchemed.1c00708⟩
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- titre
- Synthesis, Crystal Structure, Inhibitory Activity and Molecular Docking of Coumarins/Sulfonamides Containing Triazolyl Pyridine Moiety as Potent Selective Carbonic Anhydrase IX and XII Inhibitors
- auteur
- Yassine Aimene, Romain Eychenne, Frédéric Rodriguez, Sonia Mallet-Ladeira, Nathalie Saffon-Merceron, Jean-Yves Winum, Alessio Nocentini, Claudiu Supuran, Eric Benoist, Achour Seridi
- article
- Crystals, 2021, 11 (9), pp.1076. ⟨10.3390/cryst11091076⟩
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- titre
- Hypoxia-activated prodrug derivatives of anti-cancer drugs: a patent review 2006 – 2021
- auteur
- Jean-Yves Winum, Emilie Anduran, Ludwig Dubois, Philippe Lambin
- article
- Expert Opinion on Therapeutic Patents, 2021, pp.1-12. ⟨10.1080/13543776.2021.1954617⟩
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- titre
- Addition to “Reactions: An Innovative and Fun Hybrid Game to Engage the Students Reviewing Organic Reactions in the Classroom”: Using the Game Remotely during the COVID-19 Pandemic
- auteur
- José Nunes da Silva Júnior, Mary Anne Sousa Lima, Ulisses Silva de Sousa, David Macedo Do Nascimento, Antonio José Melo Leite Junior, Kimberly Benedetti Vega, Béatrice Roy, Jean-Yves Winum
- article
- Journal of Chemical Education, 2021, 98 (8), pp.2735-2737. ⟨10.1021/acs.jchemed.1c00669⟩
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- titre
- HSG400 – Design, implementation, and evaluation of a hybrid board game for aiding chemistry and chemical engineering students in the review of stereochemistry during and after the COVID-19 pandemic
- auteur
- José Nunes da Silva Júnior, Antonio José Melo Leite Junior, Jean-Yves Winum, Andrea Basso, Ulisses Silva de Sousa, David Macedo Do Nascimento, Samuel Moura Alves
- article
- Education for Chemical Engineers, 2021, 36, pp.90-99. ⟨10.1016/j.ece.2021.04.004⟩
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- titre
- Design, synthesis and photoluminescent studies of new 1,5-benzodiazepines derivatives: Towards new ESIPT compounds
- auteur
- Chiraz Ismail, Hasan Mtiraoui, Jean-Yves Winum, Moncef Msaddek, Rafik Gharbi
- article
- Tetrahedron, 2021, 86, pp.132078. ⟨10.1016/j.tet.2021.132078⟩
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- titre
- The Hunt for Maya Purple: Revisiting Ancient Pigments Syntheses and Properties
- auteur
- Jean-Yves Winum, Laurent Bernaud, Jean-Sébastien Filhol
- article
- Journal of Chemical Education, 2021, 98 (4), pp.1389-1396. ⟨10.1021/acs.jchemed.0c01306⟩
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- titre
- Response to Perspectives on the Classical Enzyme Carbonic Anhydrase and the Search for Inhibitors
- auteur
- Andrea Angeli, Fabrizio Carta, Alessio Nocentini, Jean-Yves Winum, Raivis Zalubovskis, Valentina Onnis, Wagdy Eldehna, Clemente Capasso, Simone Carradori, William Donald, Shoukat Dedhar, Claudiu Supuran
- article
- Biophysical Journal, 2021, 120 (1), pp.178-181. ⟨10.1016/j.bpj.2020.11.011⟩
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- titre
- Design, implementation, and evaluation of a game-based application for aiding chemical engineering and chemistry students to review the organic reactions
- auteur
- José Nunes da Silva Júnior, Mary Anne Sousa Lima, Antônia Torres Ávila Pimenta, Fátima Miranda Nunes, Álvaro Carvalho Monteiro, Ulisses Silva de Sousa, Antonio José Melo Leite Junior, Dávila Zampieri, Francisco Serra Oliveira Alexandre, Ulisses Silva de Sousa, Natalia Lorena Pacioni, Jean-Yves Winum
- article
- Education for Chemical Engineers, 2021, 34, pp.106-114. ⟨10.1016/j.ece.2020.11.007⟩
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- titre
- Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase
- auteur
- Jean-Yves Winum, Alessio Nocentini, Andrea Angeli, Fabrizio Carta, Raivis Zalubovskis, Simone Carradori, Clemente Capasso, William Donald, Claudiu Supuran
- article
- Journal of Enzyme Inhibition and Medicinal Chemistry, 2021, 36 (1), pp.561-580. ⟨10.1080/14756366.2021.1882453⟩
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Book sections
- titre
- Nanostructures and innovative delivery systems for overcoming cancer resistance
- auteur
- Jean-Yves Winum
- article
- Claudiu T. Supuran; Simone Carradori. pH-Interfering Agents as Chemosensitizers in Cancer Therapy: Cancer Sensitizing Agents for Chemotherapy, Elsevier, pp.185-201, 2021, 978-0-12-820701-7. ⟨10.1016/B978-0-12-820701-7.00002-6⟩
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Books
- titre
- Chimie - 2e éd. Les manuels visuels pour la licence
- auteur
- Perrio Stéphane, Béatrice Roy, Jean-Yves Winum
- article
- Dunod. 2021, 978-2100825899
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2020
Journal articles
- titre
- A Novel Inhibitor of Carbonic Anhydrases Prevents Hypoxia-Induced TNBC Cell Plasticity
- auteur
- Annachiara Sarnella, Giuliana D’avino, Billy Samuel Hill, Vincenzo Alterio, Jean-Yves Winum, Claudiu T Supuran, Giuseppina de Simone, Antonella Zannetti
- article
- International Journal of Molecular Sciences, 2020, 21 (21), pp.8405. ⟨10.3390/ijms21218405⟩
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- titre
- Interactions 500: Design, Implementation, and Evaluation of a Hybrid Board Game for Aiding Students in the Review of Intermolecular Forces During the COVID-19 Pandemic
- auteur
- José Nunes da Silva Júnior, José Mariano de Sousa Oliveira, Jean-Yves Winum, Antonio José Melo Leite Junior, Francisco Serra Oliveira Alexandre, David Macedo Do Nascimento, Ulisses Silva de Sousa, Antônia Torres Ávila Pimenta, André Jalles Monteiro
- article
- Journal of Chemical Education, 2020, 97 (11), pp.4049-4054. ⟨10.1021/acs.jchemed.0c01025⟩
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- titre
- Benzoxaboroles: New Potent Inhibitors of the Carbonic Anhydrases of the Pathogenic Bacterium Vibrio cholerae
- auteur
- Alessandro Bonardi, Alessio Nocentini, Roberta Cadoni, Sonia del Prete, Pascal Dumy, Clemente Capasso, Paola Gratteri, Claudiu Supuran, Jean-Yves Winum
- article
- ACS Medicinal Chemistry Letters, 2020, 11 (11), pp.2277-2284. ⟨10.1021/acsmedchemlett.0c00403⟩
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- titre
- Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–7
- auteur
- Michael Gütschow, Jean Jacques Vanden Eynde, Josef Jampilek, Congbao Kang, Arduino Aleksander Mangoni, Paola Fossa, Rafik Karaman, Andrea Trabocchi, Peter Scott, Jóhannes Reynisson, Simona Rapposelli, Stefania Galdiero, Jean-Yves Winum, Chiara Brullo, Katalin Prokai-Tatrai, Arun Sharma, Matthieu Schapira, Yasu-Taka Azuma, Laura Cerchia, Mariana Spetea, Giangiacomo Torri, Simona Collina, Athina Geronikaki, Alfonso García-Sosa, M. Helena Vasconcelos, Maria Emília de Sousa, Ivan Kosalec, Tiziano Tuccinardi, Iola Duarte, Jorge Salvador, Massimo Bertinaria, Maurizio Pellecchia, Jussara Amato, Giulio Rastelli, Paula Gomes, Rita Guedes, Jean-Marc Sabatier, Ana Estévez-Braun, Bruno Pagano, Stefano Mangani, Rino Ragno, George Kokotos, Margherita Brindisi, Florenci González, Fernanda Borges, Mariarosaria Miloso, Jarkko Rautio, Diego Muñoz-Torrero
- article
- Molecules, 2020, 25 (13), pp.2968. ⟨10.3390/molecules25132968⟩
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- titre
- Targeting the Human 80S Ribosome in Cancer: From Structure to Function and Drug Design for Innovative Adjuvant Therapeutic Strategies
- auteur
- Arnaud Gilles, Léo Frechin, Kundhavai Natchiar, Giulia Biondani, Ottilie Von Loeffelholz, Samuel Holvec, Julie-Lisa Malaval, Jean-Yves Winum, Bruno Klaholz, Jean-François Peyron
- article
- Cells, 2020, 9 (3), pp.629. ⟨10.3390/cells9030629⟩
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-
- titre
- Reactions: An Innovative and Fun Hybrid Game to Engage the Students Reviewing Organic Reactions in the Classroom
- auteur
- José Nunes da Silva Júnior, Mary Anne Sousa Lima, Ulisses Silva de Sousa, David Macedo Do Nascimento, Antonio José Melo Leite Junior, Kimberly Benedetti Vega, Béatrice Roy, Jean-Yves Winum
- article
- Journal of Chemical Education, 2020, 97 (3), pp.749-753. ⟨10.1021/acs.jchemed.9b01020⟩
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- titre
- Design, synthesis, in vitro inhibition and toxicological evaluation of human carbonic anhydrases I, II and IX inhibitors in 5-nitroimidazole series
- auteur
- Ashok Aspatwar, Nanda Kumar Parvathaneni, Harlan Barker, Emilie Anduran, Claudiu Supuran, Ludwig Dubois, Philippe Lambin, Seppo Parkkila, Jean-Yves Winum
- article
- Journal of Enzyme Inhibition and Medicinal Chemistry, 2020, 35 (1), pp.109-117. ⟨10.1080/14756366.2019.1685510⟩
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-
- titre
- Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–6
- auteur
- Jean Jacques Vanden Eynde, Arduino Aleksander Mangoni, Jarkko Rautio, Jérôme Leprince, Yasu-Taka Azuma, Alfonso García-Sosa, Christopher Hulme, Josef Jampilek, Rafik Karaman, Wei Li, Paula Gomes, Dimitra Hadjipavlou-Litina, Raffaele Capasso, Athina Geronikaki, Laura Cerchia, Jean-Marc Sabatier, Rino Ragno, Rino Ragno, Tiziano Tuccinardi, Andrea Trabocchi, Jean-Yves Winum, F Javier Luque, Katalin Prokai-Tatrai, Mariana Spetea, Michael Gütschow, Ivan Kosalec, Catherine Guillou, M. Helena Vasconcelos, George Kokotos, Giulio Rastelli, Maria Emília de Sousa, Clementina Manera, Sandra Gemma, Stefano Mangani, Luigi A Agrofoglio, Carlo Siciliano, Stefania Galdiero, Hong Liu, Peter Scott, Cristóbal de Los Ríos, Simona Collina, Rita Guedes, Diego Muñoz-Torrero
- article
- Molecules, 2020, 25 (1), pp.119. ⟨10.3390/molecules25010119⟩
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- titre
- Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment
- auteur
- Andrea Angeli, Fabrizio Carta, Alessio Nocentini, Jean-Yves Winum, Raivis Zalubovskis, Atilla Akdemir, Valentina Onnis, Wagdy Eldehna, Clemente Capasso, Giuseppina De Simone, Simona Maria Monti, Simone Carradori, William Donald, Shoukat Dedhar, Claudiu Supuran
- article
- Metabolites, 2020, 10 (10), pp.412. ⟨10.3390/metabo10100412⟩
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-
- titre
- Hypoxia-Activated Prodrug Derivatives of Carbonic Anhydrase Inhibitors in Benzenesulfonamide Series: Synthesis and Biological Evaluation
- auteur
- Emilie Anduran, Ashok Aspatwar, Nanda-Kumar Parvathaneni, Dennis Suylen, Silvia Bua, Alessio Nocentini, Seppo Parkkila, Claudiu Supuran, Ludwig Dubois, Philippe Lambin, Jean-Yves Winum
- article
- Molecules, 2020, 25 (10), pp.2347. ⟨10.3390/molecules25102347⟩
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Books
- titre
- Chimie L1
- auteur
- Stéphane Perrio, Béatrice Roy, Jean Yves Winum
- article
- Dunod, 213 p., 2020, Je me trompe, donc j’apprends !, 978-2-10-079565-9
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2019
Journal articles
- titre
- Multivalent Carbonic Anhydrases Inhibitors
- auteur
- Fabrizio Carta, Pascal Dumy, Claudiu Supuran, Jean‐yves Winum
- article
- International Journal of Molecular Sciences, 2019, 20 (21), pp.5352. ⟨10.3390/ijms20215352⟩
- Accès au texte intégral et bibtex
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- titre
- Novel method of treating macular degeneration: a patent evaluation (WO2018/107005)
- auteur
- Jean-Yves Winum, Clemente Capasso
- article
- Expert Opinion on Therapeutic Patents, 2019, 29 (10), pp.749-752. ⟨10.1080/13543776.2019.1661991⟩
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- titre
- N-aryl-N’-ureido-O-sulfamates: Potent and selective inhibitors of the human Carbonic Anhydrase VII isoform with neuropathic pain relieving properties
- auteur
- Jean-Yves Winum, Murat Bozdag, Giulio Poli, Andrea Angeli, Elena Lucarini, Tiziano Tuccinardi, Lorenzo Di Cesare Mannelli, Silvia Selleri, Carla Ghelardini, Fabrizio Carta, Claudiu Supuran
- article
- Bioorganic Chemistry, 2019, 89, pp.103033. ⟨10.1016/j.bioorg.2019.103033⟩
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- titre
- Inhibitors of Selected Bacterial Metalloenzymes
- auteur
- Raivis Žalubovskis, Jean-Yves Winum
- article
- Current Medicinal Chemistry, 2019, 26 (15), pp.2690-2714. ⟨10.2174/0929867325666180403154018⟩
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- titre
- Metalloenzymes as Therapeutic Targets
- auteur
- Jean-Yves Winum, Barbara Richichi, Georgios Spyroulias, Raivis Žalubovskis
- article
- Current Medicinal Chemistry, 2019, 26 (15), pp.2556-2557. ⟨10.2174/092986732615190725122012⟩
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- titre
- Bis-benzoxaboroles: Design, Synthesis, and Biological Evaluation as Carbonic Anhydrase Inhibitors
- auteur
- Adèle Larcher, Alessio Nocentini, Claudiu T. Supuran, Jean-Yves Winum, Arie van Der Lee, Jean-Jacques Vasseur, Danielle Laurencin, Michaël Smietana
- article
- ACS Medicinal Chemistry Letters, 2019, 10 (8), pp.1205-1210. ⟨10.1021/acsmedchemlett.9b00252⟩
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- titre
- Novel Re(I) tricarbonyl coordination compounds based on 2-pyridyl-1,2,3-triazole derivatives bearing a 4-amino-substituted benzenesulfonamide arm: synthesis, crystal structure, computational studies and inhibitory activity against carbonic anhydrase I, II, and IX isoforms†
- auteur
- Yassine Aimene, Romain Eychenne, Sonia Mallet-Ladeira, Nathalie Saffon, Jean-Yves Winum, Alessio Nocentini, Claudiu T. Supuran, Eric Benoist, Achour Seridi
- article
- Journal of Enzyme Inhibition and Medicinal Chemistry, 2019, 34 (1), pp.773-782. ⟨10.1080/14756366.2019.1585835⟩
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- titre
- (Hetero)aryl substituted thiazol-2,4-yl scaffold as human carbonic anhydrase I, II, VII and XIV activators
- auteur
- Marouan Rami, Jean-Yves Winum, Claudiu T Supuran, Patricia Melnyk, Saïd Yous
- article
- Journal of Enzyme Inhibition and Medicinal Chemistry, 2019, 34 (1), pp.224-229. ⟨10.1080/14756366.2018.1543292⟩
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- titre
- Exploring benzoxaborole derivatives as carbonic anhydrase inhibitors: a structural and computational analysis reveals their conformational variability as a tool to increase enzyme selectivity
- auteur
- Jean-Yves Winum, Emma Langella, Vincenzo Alterio, Katia d'Ambrosio, Roberta Cadoni, Claudiu Supuran, Simona Maria Monti, Giuseppina de Simone, Anna Di Fiore
- article
- Journal of Enzyme Inhibition and Medicinal Chemistry, 2019, 34 (1), pp.1498-1505. ⟨10.1080/14756366.2019.1653291⟩
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Book sections
- titre
- Carbonic anhydrase inhibitors for the treatment of tumors
- auteur
- Jean-Yves Winum, Marc Ilies
- article
- Carbonic Anhydrases, Elsevier, pp.331-365, 2019, ⟨10.1016/B978-0-12-816476-1.00016-2⟩
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Books
- titre
- Mémo visuel de chimie générale
- auteur
- Isabelle Bonnamour, Jean-Sébastien Filhol, Frédéric Lemoigno, Jean-Yves Winum, Nathalie Perol
- article
- Dunod, 2019, 978-2100767076
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Poster communications
- titre
- Benzenesulfonamide-based tricarbonyl rhenium complexes as new carbonic anhydrase ix inhibitors
- auteur
- Yassine Aimene, Romain Eychenne, Jean Yves Winum, Alessio Nocentini, Claudiu T. Supuran, Eric Benoist, Achour Seridi
- article
- 10th International Chemistry Conference Toulouse-Kiev (ICTK-10), Jun 2019, Toulouse, France
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2018
Journal articles
- titre
- Carbonic anhydrase enzymes for regulating mast cell hematopoiesis and type-2 inflammation: a patent evaluation (WO2017/058370)
- auteur
- Jean-Yves Winum
- article
- Expert Opinion on Therapeutic Patents, 2018, 28 (10), pp.741-743. ⟨10.1080/13543776.2018.1501472⟩
- Accès au bibtex
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- titre
- Benzoxaborole compounds for therapeutic uses: a patent review (2010-2018)
- auteur
- Jean-Yves Winum
- article
- Expert Opinion on Therapeutic Patents, 2018, 28 (6), pp.vii-vii. ⟨10.1080/13543776.2018.1480336⟩
- Accès au bibtex
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- titre
- Benzoxaborole compounds for therapeutic uses: a patent review (2010- 2018)
- auteur
- Alessio Nocentini, Claudiu Supuran, Jean-Yves Winum
- article
- Expert Opinion on Therapeutic Patents, 2018, 28 (6), pp.493-504. ⟨10.1080/13543776.2018.1473379⟩
- Accès au bibtex
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- titre
- Nitroimidazole-based inhibitors DTP338 and DTP348 are safe for zebrafish embryos and efficiently inhibit the activity of human CA IX in Xenopus oocytes
- auteur
- Ashok Aspatwar, Holger Becker, Nanda Kumar Parvathaneni, Milka Hammaren, Aleksandra Svorjova, Harlan Barker, Claudiu Supuran, Ludwig Dubois, Philippe Lambin, Mataleena Parikka, Seppo Parkkila, Jean-Yves Winum
- article
- Journal of Enzyme Inhibition and Medicinal Chemistry, 2018, 33 (1), pp.1064-1073. ⟨10.1080/14756366.2018.1482285⟩
- Accès au texte intégral et bibtex
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- titre
- Carbonic anhydrases from Trypanosoma cruzi and Leishmania donovani chagasi are inhibited by benzoxaboroles
- auteur
- Alessio Nocentini, Roberta Cadoni, Pascal Dumy, Claudiu Supuran, Jean-Yves Winum
- article
- Journal of Enzyme Inhibition and Medicinal Chemistry, 2018, 33 (1), pp.286-289. ⟨10.1080/14756366.2017.1414808⟩
- Accès au texte intégral et bibtex
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- titre
- Inhibition of carbonic anhydrases by a substrate analog: benzyl carbamate directly coordinates the catalytic zinc ion mimicking bicarbonate binding
- auteur
- Giuseppina de Simone, Andrea Angeli, Murat Bozdag, Claudiu Supuran, Jean-Yves Winum, Simona Maria Monti, Vincenzo Alterio
- article
- Chemical Communications, 2018, 54 (73), pp.10312-10315. ⟨10.1039/c8cc05755a⟩
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- titre
- Carbonic Anhydrase Inhibitors as Novel Drugs against Mycobacterial β-Carbonic Anhydrases: An Update on In Vitro and In Vivo Studies
- auteur
- Ashok Aspatwar, Jean-Yves Winum, Fabrizio Carta, Claudiu Supuran, Milka Hammaren, Mataleena Parikka, Seppo Parkkila
- article
- Molecules, 2018, 23 (11), pp.2911. ⟨10.3390/molecules23112911⟩
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-
2017
Journal articles
- titre
- Benzoxaboroles as Efficient Inhibitors of the β-Carbonic Anhydrases from Pathogenic Fungi: Activity and Modeling Study
- auteur
- Alessio Nocentini, Roberta Cadoni, Sonia del Prete, Clemente Capasso, Pascal Dumy, Paola Gratteri, Claudiu Supuran, Jean-Yves Winum
- article
- ACS Medicinal Chemistry Letters, 2017, 8 (11), pp.1194-1198. ⟨10.1021/acsmedchemlett.7b00369⟩
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- titre
- Cover Feature: Polyhedral Oligomeric Silsesquioxane (POSS) Bearing Glyoxylic Aldehyde as Clickable Platform Towards Multivalent Conjugates (Chem. Eur. J. 71/2017)
- auteur
- Nasreddine Kanfar, Ahmad Mehdi, Pascal Dumy, Sébastien Ulrich, Jean‐Yves Winum
- article
- Chemistry - A European Journal, 2017, 23 (71), pp.17837-17837. ⟨10.1002/chem.201704700⟩
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- titre
- Polyhedral Oligomeric Silsesquioxane (POSS) Bearing Glyoxylic Aldehyde as Clickable Platform Towards Multivalent Conjugates
- auteur
- Nasreddine Kanfar, Ahmad Mehdi, Pascal Dumy, Sebastien Ulrich,, Jean-Yves Winum
- article
- Chemistry - A European Journal, 2017, 23, pp.1-4. ⟨10.1002/chem.201703794⟩
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-
- titre
- Anion inhibitors of the β-carbonic anhydrase from the pathogenic bacterium responsible of tularemia, Francisella tularensis
- auteur
- Sonia del Prete, Daniela Vullo, Sameh Osman, Zeid Alothman, William Donald, Jean-Yves Winum, Claudiu Supuran, Clemente Capasso
- article
- Bioorganic and Medicinal Chemistry, 2017, 25 (17), pp.4800-4804. ⟨10.1016/j.bmc.2017.07.033⟩
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- titre
- Co-targeting intracellular pH and essential amino acid uptake cooperates to induce cell death of T-ALL/LL cells
- auteur
- Véronique Imbert, Marielle Nebout, Didier Mary, Hitoshi Endou, Michael Wempe, Claudiu Supuran, Jean-Yves Winum, Jean-François Peyron
- article
- Leukemia & lymphoma, 2017, 59 (2), pp.460-468. ⟨10.1080/10428194.2017.1339875⟩
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- titre
- Effective Access to Multivalent Inhibitors of Carbonic Anhydrases Promoted by Peptide Bioconjugation
- auteur
- Nasreddine Kanfar, Muhammet Tanc, Pascal Dumy, Claudiu Supuran, Sébastien Ulrich, Jean-Yves Winum
- article
- Chemistry - A European Journal, 2017, 23 (28), pp.6788-6794. ⟨10.1002/chem.201700241⟩
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- titre
- New approach of delivering cytotoxic drugs towards CAIX expressing cells: A concept of dual-target drugs
- auteur
- Simon van Kuijk, Nanda Kumar Parvathaneni, Raymon Niemans, Marike van Gisbergen, Fabrizio Carta, Daniela Vullo, Silvia Pastorekova, Ala Yaromina, Claudiu Supuran, Ludwig Dubois, Jean-Yves Winum, Philippe Lambin
- article
- European Journal of Medicinal Chemistry, 2017, 127, pp.691 - 702. ⟨10.1016/j.ejmech.2016.10.037⟩
- Accès au texte intégral et bibtex
-
- titre
- Brucella suis carbonic anhydrases and their inhibitors: Towards alternative antibiotics?
- auteur
- Stephan Köhler, Safia Ouahrani-Bettache, Jean-Yves Winum
- article
- Journal of Enzyme Inhibition and Medicinal Chemistry, 2017, 32 (1), pp.683-687. ⟨10.1080/14756366.2017.1295451⟩
- Accès au texte intégral et bibtex
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- titre
- Insights into the binding mode of sulphamates and sulphamides to hCA II: crystallographic studies and binding free energy calculations
- auteur
- Giuseppina de Simone, Emma Langella, Davide Esposito, Claudiu Supuran, Simona Maria Monti, Jean-Yves Winum, Vincenzo Alterio
- article
- Journal of Enzyme Inhibition and Medicinal Chemistry, 2017, 32 (1), pp.1002-1011. ⟨10.1080/14756366.2017.1349764⟩
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-
Books
- titre
- Chimie 1er Ed Les manuels visuels pour la licence
- auteur
- Perrio Stéphane, Béatrice Roy, Jean-Yves Winum
- article
- Dunod. 2017, 978-2100748310
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- titre
- Chimie
- auteur
- Perrio Stéphane, Béatrice Roy, Jean-Yves Winum
- article
- Dunod, 420 p., 2017, Fluoresciences, 9782100748310
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2016
Journal articles
- titre
- Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors: a patent evaluation of US20160011199A1
- auteur
- Jean-Yves Winum
- article
- Expert Opinion on Therapeutic Patents, 2016, 26 (11), pp.1223-1226. ⟨10.1080/13543776.2016.1241238⟩
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- titre
- The anticonvulsant sulfamide JNJ-26990990 and its S,S-dioxide analog strongly inhibit carbonic anhydrases: solution and X-ray crystallographic studies
- auteur
- Anna Di Fiore, Giuseppina de Simone, Vincenzo Alterio, Vincenzo Riccio, Jean-Yves Winum, Fabrizio Carta, Claudiu Supuran
- article
- Organic & Biomolecular Chemistry, 2016, 14 (21), pp.4853-4858. ⟨10.1039/C6OB00803H⟩
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- titre
- Benzoxaborole as a new chemotype for carbonic anhydrase inhibition
- auteur
- Vincenzo Alterio, Roberta Cadoni, Davide Esposito, Daniela Vullo, Anna Di Fiore, Simona Maria Monti, Andrea Caporale, Menotti Ruvo, Mario Sechi, Pascal Dumy, Claudiu Supuran, Giuseppina De Simone, Jean-Yves Winum
- article
- Chemical Communications, 2016, 52 (80), pp.11983-11986. ⟨10.1039/c6cc06399c⟩
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2015
Journal articles
- titre
- Evaluation of carbonic anhydrase IX as a therapeutic target for inhibition of breast cancer invasion and metastasis using a series of in vitro breast cancer models
- auteur
- Carol Ward, James Meehan, Peter Mullen, Claudiu Supuran, J. Michael Dixon, Jeremy Thomas, Jean-Yves Winum, Philippe Lambin, Ludwig Dubois, Nanda-Kumar Pavathaneni, Edward Jarman, Lorna Renshaw, In Hwa Um, Charlene Kay, David Harrison, Ian Kunkler, Simon Langdon
- article
- Oncotarget, 2015, 6 (28), pp.24856-24870. ⟨10.18632/oncotarget.4498⟩
- Accès au texte intégral et bibtex
-
- titre
- Emerging trends in enzyme inhibition by multivalent nanoconstructs
- auteur
- Nasreddine Kanfar, Eline Bartolami, Renaud Zelli, Alberto Marra, Jean-Yves Winum, Sébastien Ulrich, Pascal Dumy
- article
- Organic & Biomolecular Chemistry, 2015, 13 (39), pp.9894-9906. ⟨10.1039/C5OB01405K⟩
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- titre
- Carbonic anhydrase IX inhibitors in cancer therapy: an update
- auteur
- Claudiu Supuran, Jean-Yves Winum
- article
- Future Medicinal Chemistry, 2015, 7 (11), pp.1407-1414. ⟨10.4155/fmc.15.71⟩
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- titre
- Carbonic Anhydrase Glycoinhibitors belonging to the Aminoxysulfonamide Series
- auteur
- Joanna Ombouma, Daniella Vullo, Pascal Dumy, Claudiu Supuran, Jean-Yves Winum
- article
- ACS Medicinal Chemistry Letters, 2015, 6 (7), pp.819-821. ⟨10.1021/acsmedchemlett.5b00175⟩
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- titre
- Poly(amidoamine) Dendrimers with Carbonic Anhydrase Inhibitory Activity and Antiglaucoma Action
- auteur
- Fabrizio Carta, Sameh Osman, Daniela Vullo, Antonella Gullotto, Jean-Yves Winum, Zeid Alothman, Emanuela Masini, Claudiu Supuran
- article
- Journal of Medicinal Chemistry, 2015, 58 (9), pp.4039-4045. ⟨10.1021/acs.jmedchem.5b00383⟩
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-
- titre
- Designing carbonic anhydrase inhibitors for the treatment of breast cancer
- auteur
- Claudiu Supuran, Jean-Yves Winum
- article
- Expert Opinion on Drug Discovery, 2015, 10 (6), pp.591-597. ⟨10.1517/17460441.2015.1038235⟩
- Accès au bibtex
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- titre
- Recent advances in the discovery of zinc-binding motifs for the development of carbonic anhydrase inhibitors
- auteur
- Jean-Yves Winum, Claudiu Supuran
- article
- Journal of Enzyme Inhibition and Medicinal Chemistry, 2015, 30 (2), pp.321-324. ⟨10.3109/14756366.2014.913587⟩
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-
- titre
- Fluorescent Silica Nanoparticles with Multivalent Inhibitory Effects towards Carbonic Anhydrases
- auteur
- Nadia Touisni, Nasreddine Kanfar, Sebastien Ulrich,, Pascal Dumy, Claudiu T Supuran, Ahmad Mehdi, Jean-Yves Winum
- article
- Chemistry - A European Journal, 2015, ⟨10.1002/chem.201501037⟩
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-
- titre
- Binding of Carbonic Anhydrase IX to 45S rDNA Genes Is Prevented by Exportin-1 in Hypoxic Cells
- auteur
- Emanuele Sasso, Monica Vitale, Francesca Monteleone, Francesca Ludovica Boffo, Margherita Santoriello, Daniela Sarnataro, Corrado Garbi, Mariangela Sabatella, Bianca Crifò, Luca Alfredo Paolella, Giuseppina Minopoli, Jean-Yves Winum, Nicola Zambrano
- article
- BioMed Research International , 2015, 2015, pp.674920. ⟨10.1155/2015/674920⟩
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-
- titre
- Hydroxylamine-O-sulfonamide is a versatile lead compound for the development of carbonic anhydrase inhibitors
- auteur
- Anna Di Fiore, Alessandro Vergara, Marco Caterino, Vincenzo Alterio, Simona Monti, Joanna Ombouma, Pascal Dumy, Daniela Vullo, Claudiu Supuran, Jean-Yves Winum, Giuseppina de Simone
- article
- Chemical Communications, 2015, 51 (57), pp.11519-11522. ⟨10.1039/C5CC03711E⟩
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-
- titre
- New ways to image and target tumour hypoxia and its molecular responses
- auteur
- Ludwig Dubois, Raymon Niemans, Simon J.A. van Kuijk, Kranthi Panth, Nanda-Kumar Parvathaneni, Sarah G.J.A. Peeters, Catharina M.L. Zegers, Nicolle Rekers, Marike van Gisbergen, Rianne Biemans, Natasja Lieuwes, Linda Spiegelberg, Ala Yaromina, Jean-Yves Winum, Marc Vooijs, Philippe Lambin
- article
- Radiotherapy & Oncology, 2015, 116 (3), pp.352 - 357. ⟨10.1016/j.radonc.2015.08.022⟩
- Accès au texte intégral et bibtex
-
2014
Journal articles
- titre
- N-glycosyl-N-hydroxysulfamides as potent inhibitors of Brucella suis carbonic anhydrases
- auteur
- Joanna Ombouma, Daniela Vullo, Stephan Köhler, Pascal Dumy, Claudiu T. Supuran, Jean-Yves Winum
- article
- Journal of Enzyme Inhibition and Medicinal Chemistry, 2014, 30 (6), pp.1010-1012. ⟨10.3109/14756366.2014.986119⟩
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- titre
- Inhibition of β -carbonic anhydrases from Brucella suis with C -cinnamoyl glycosides incorporating the phenol moiety
- auteur
- Leonardo Riafrecha, Daniela Vullo, Safia Ouahrani-Bettache, Stephan Köhler, Pascal Dumy, Jean-Yves Winum, Claudiu T. Supuran, Pedro Colinas
- article
- Journal of Enzyme Inhibition and Medicinal Chemistry, 2014, 30 (6), pp.1017-1020. ⟨10.3109/14756366.2014.986120⟩
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- titre
- Oxo- and thiooxo-imidazo[1,5-c]pyrimidine molecule library: Beyond their interest in inhibition of Brucella suis histidinol dehydrogenase, a powerful protection tool in the synthesis of histidine analogues
- auteur
- François Turtaut, Marie Lopez, Safia Ouahrani-Bettache, Stephan Köhler, Jean-Yves Winum
- article
- Bioorganic and Medicinal Chemistry Letters, 2014, 24 (21), pp.5008-5010. ⟨10.1016/j.bmcl.2014.09.020⟩
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-
- titre
- Ferrier sulfamidoglycosylation of glycals catalyzed by nitrosonium tetrafluoroborate: Towards new carbonic anhydrase glycoinhibitors
- auteur
- Joanna Ombouma, Daniela Vullo, Claudiu Supuran, Jean-Yves Winum
- article
- Bioorganic and Medicinal Chemistry, 2014, 22 (22), pp.6353-6359. ⟨10.1016/j.bmc.2014.09.053⟩
- Accès au bibtex
-
- titre
- Mono- and di-halogenated histamine, histidine and carnosine derivatives are potent carbonic anhydrase I, II, VII, XII and XIV activators
- auteur
- Mohamed-Chiheb Saada, Daniela Vullo, Jean-Louis Montero, Andrea Scozzafava, Claudiu Supuran, Jean-Yves Winum
- article
- Bioorganic and Medicinal Chemistry, 2014, 22 (17), pp.4752-4758. ⟨10.1016/j.bmc.2014.07.005⟩
- Accès au bibtex
-
- titre
- Metal-based carboxamide-derived compounds endowed with antibacterial and antifungal activity
- auteur
- Muhammad Hanif, Zahid Chohan, Jean-Yves Winum, Javeed Akhtar
- article
- Journal of Enzyme Inhibition and Medicinal Chemistry, 2014, 29 (4), pp.517-526. ⟨10.3109/14756366.2013.815178⟩
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- titre
- Carbonic anhydrase inhibitors. Inhibition of human cytosolic isoforms I and II with (reduced) Schiff’s bases incorporating sulfonamide, carboxylate and carboxymethyl moieties
- auteur
- Gihane Nasr, Alina Cristian, Mihail Barboiu, Daniella Vullo, Jean-Yves Winum, Claudiu T. Supuran
- article
- Bioorganic and Medicinal Chemistry, 2014, 22 (10), pp.2867 - 2874. ⟨10.1016/j.bmc.2014.03.041⟩
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- titre
- Structural basis for the rational design of new anti-Brucella agents: The crystal structure of the C366S mutant of l-histidinol dehydrogenase from Brucella suis
- auteur
- Katia d'Ambrosio, Marie Lopez, Nina Dathan, Safia Ouahrani-Bettache, Stephan Köhler, Giuseppina Ascione, Simona Maria Monti, Jean-Yves Winum, Giuseppina de Simone
- article
- Biochimie, 2014, 97, pp.114-120. ⟨10.1016/j.biochi.2013.09.028⟩
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- titre
- Dominant behaviours in the expression of human carbonic anhydrase hCA I activity
- auteur
- M. Yahia M. Abdelrahim, Muhammet Tanc, Jean-Yves Winum, Claudiu T. Supuran, Mihail Barboiu
- article
- Chemical Communications, 2014, 50 (59), pp.8043 - 8046. ⟨10.1039/c4cc03289f⟩
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-
Conference papers
- titre
- Chiral water systems – CHIRAWATER
- auteur
- Mihail Barboiu, Benoit Coasne, Jean-Yves Winum, Yves-Marie Legrand, Zhanhu Sun, Arie van Der Lee
- article
- Journées Présentations et bilans des projets lauréats 2012, 2013 et 2014 du LabEx CheMISyst, Oct 2014, Montpellier, France
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2013
Journal articles
- titre
- Hypoxia-Targeting Carbonic Anhydrase IX Inhibitors by a New Series of Nitroimidazole-Sulfonamides/Sulfamides/Sulfamates
- auteur
- Marouan Rami, Ludwig Dubois, Nanda-Kumar Parvathaneni, Vincenzo Alterio, Simon van Kuijk, Simona Maria Monti, Philippe Lambin, Giuseppina de Simone, Claudiu Supuran, Jean-Yves Winum
- article
- Journal of Medicinal Chemistry, 2013, 56 (21), pp.8512-8520. ⟨10.1021/jm4009532⟩
- Accès au texte intégral et bibtex
-
- titre
- Targeting carbonic anhydrase IX by nitroimidazole based sulfamides enhances the therapeutic effect of tumor irradiation: A new concept of dual targeting drugs
- auteur
- Ludwig Dubois, Sarah G.J.A. Peeters, Simon J.A. van Kuijk, Ala Yaromina, Natasja G Lieuwes, Ruchi Saraya, Rianne Biemans, Marouan Rami, Nanda Kumar Parvathaneni, Daniela Vullo, Marc Vooijs, Claudiu T Supuran, Jean-Yves Winum, Philippe Lambin
- article
- Radiotherapy & Oncology, 2013, 108 (3), pp.523-528. ⟨10.1016/j.radonc.2013.06.018⟩
- Accès au texte intégral et bibtex
-
- titre
- A spectrophotometric and thermodynamic study of the charge-transfer complexes of N-aryl-N′-isopropyloxycarbonylsulfamides with DDQ and TCNE
- auteur
- Moufida Belfaragui, Achour Seridi, Jean-Yves Winum, Mohamed Abdaoui, Mekki Kadri
- article
- Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy [1994-..], 2013, 108, pp.55-61. ⟨10.1016/j.saa.2013.01.083⟩
- Accès au bibtex
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- titre
- Metronidazole-coumarin conjugates and 3-cyano-7-hydroxy-coumarin act as isoform-selective carbonic anhydrase inhibitors
- auteur
- Adeline Bonneau, Alfonso Maresca, Jean-Yves Winum, Claudiu Supuran
- article
- Journal of Enzyme Inhibition and Medicinal Chemistry, 2013, 28 (2), pp.397-401. ⟨10.3109/14756366.2011.650692⟩
- Accès au bibtex
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- titre
- Novel antibody to a carbonic anhydrase: patent evaluation of WO2011138279A1
- auteur
- Jean-Yves Winum, Clemente Capasso
- article
- Expert Opinion on Therapeutic Patents, 2013, 23 (6), pp.757-760. ⟨10.1517/13543776.2013.776041⟩
- Accès au bibtex
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- titre
- Glycosidic carbonic anhydrase IX inhibitors: A sweet approach against cancer
- auteur
- Jean-Yves Winum, Pedro Colinas, Claudiu Supuran
- article
- Bioorganic and Medicinal Chemistry Letters, 2013, 21 (6), pp.1419-1426. ⟨10.1016/j.bmc.2012.10.043⟩
- Accès au bibtex
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- titre
- Thiol–ene click chemistry for the synthesis of highly effective glycosyl sulfonamide carbonic anhydrase inhibitors
- auteur
- Mohamed-Chiheb Saada, Joanna Ombouma, Jean-Louis Montero, Claudiu Supuran, Jean-Yves Winum
- article
- Chemical Communications, 2013, 49 (50), pp.5699-5701. ⟨10.1039/C3CC42541J⟩
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2012
Journal articles
- titre
- Zinc metalloenzymes as new targets against the bacterial pathogen Brucella
- auteur
- Marie Lopez, Stephan Köhler, Jean-Yves Winum
- article
- Journal of Inorganic Biochemistry, 2012, 111, pp.138-145. ⟨10.1016/j.jinorgbio.2011.10.019⟩
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- titre
- Inhibition of beta-carbonic anhydrases from the bacterial pathogen Brucella suis with inorganic anions
- auteur
- Alfonso Maresca, Andrea Scozzafava, Stephan Köhler, Jean-Yves Winum, Claudiu T. Supuran
- article
- Journal of Inorganic Biochemistry, 2012, 110, pp.36-39. ⟨10.1016/j.jinorgbio.2012.02.009⟩
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- titre
- Antimetastatic Effect of Sulfamate Carbonic Anhydrase IX Inhibitors in Breast Carcinoma Xenografts.
- auteur
- R.G. Gieling, M. Babur, L. Mamnani, N. Burrows, B.A. Telfer, F. Carta, Jean-Yves Winum, Andrea Scozzafava, Claudiu T. Supuran, K.J. Williams
- article
- Journal of Medicinal Chemistry, 2012, 55 (11), pp.5591-5600. ⟨10.1021/jm300529u⟩
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-
- titre
- Ureido-substituted sulfamates show potent carbonic anhydrase IX inhibitory and antiproliferative activities against breast cancer cell lines.
- auteur
- Jean-Yves Winum, Fabrizio Carta, C. Ward, P. Mullen, D. Harrison, Sp Langdon, Alessandro Cecchi, Andrea Scozzafava, Ian Kunkler, Claudiu T. Supuran
- article
- Bioorganic and Medicinal Chemistry Letters, 2012, 22, pp.4681-4685. ⟨10.1016/j.bmcl.2012.05.083⟩
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- titre
- Recent Developments in Targeting Carbonic Anhydrase IX for Cancer Therapeutics.
- auteur
- P.C. Mcdonald, Jean-Yves Winum, Claudiu T. Supuran, S. Dedhar
- article
- Oncotarget, 2012, 3, pp.84-97. ⟨10.18632/oncotarget.422⟩
- Accès au bibtex
-
- titre
- Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins.
- auteur
- G. Balboni, C. Congiu, V. Onnis, A. Maresca, Andrea Scozzafava, Jean-Yves Winum, A. Maietti, Claudiu T. Supuran
- article
- Bioorganic and Medicinal Chemistry Letters, 2012, 22 (9), pp.3063-3066. ⟨10.1016/j.bmcl.2012.03.071⟩
- Accès au bibtex
-
Book sections
- titre
- Novel targets for antibacterial agents in Brucella sp.
- auteur
- Christian Baron, Jean-Yves Winum, Stephen Kohler
- article
- Caister Academic Press. Brucella - Molecular Biology and Genomics, Horizonpress, pp.223-239, 2012
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2011
Journal articles
- titre
- A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth
- auteur
- Pascale Joseph, S. Bettache, Jean-Louis Montero, Isao Nishimori, Tomoko Minakuchi, Daniela Vullo, Andrea Scozzafava, Jean-Yves Winum, Stephan Köhler, Claudiu T. Supuran
- article
- Bioorganic and Medicinal Chemistry, 2011, 19, pp.1172-1178. ⟨10.1016/j.bmc.2010.12.048⟩
- Accès au bibtex
-
- titre
- Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors.
- auteur
- Y. Lou, P.C. Mcdonald, A. Oloumi, S. Chia, C. Ostlund, A. Ahmadi, A. Kyle, U. auf Dem Keller, S. Leung, D. Huntsman, B. Clarke, B.W. Sutherland, D. Waterhouse, M. Bally, C.M. Roskelley, Christopher M Overall, A. Minchinton, A. Pacchiano, F. Carta, Nadia Touisni, Jean-Yves Winum, Claudiu T. Supuran, S. Dedhar
- article
- Cancer Research, 2011, 71, pp.3364-3376. ⟨10.1158/0008-5472.CAN-10-4261⟩
- Accès au bibtex
-
- titre
- Synthesis and biological evaluation of a new class of anti-Brucella compounds targeting histidinol dehydrogenase: alpha-O-arylketones and alph-S-arylketones derived from histidine.
- auteur
- François Turtaut, S. Ouahrani-Bettache, Jean-Louis Montero, Stephan Köhler, Jean-Yves Winum
- article
- MedChemComm, 2011, 2, pp.995-1000. ⟨10.1039/C1MD00146A⟩
- Accès au bibtex
-
- titre
- Anti-virulence Strategy against Brucella suis: Synthesis, Biological Evaluation and Molecular Modeling of Selective Histidinol Dehydrogenase Inhibitors
- auteur
- Marie-Rose Abdo, Pascale Joseph, Jérémie Mortier, François Turtaut, Jean-Louis Montero, Bernard Masereel, Stephan Köhler, Jean-Yves Winum
- article
- Organic & Biomolecular Chemistry, 2011, 9 (10), pp.3681. ⟨10.1039/c1ob05149k⟩
- Accès au bibtex
-
- titre
- Glycosyl coumarin carbonic anhydrase IX and XII inhibitors strongly attenuate the growth of primary breast tumors.
- auteur
- Nadia Touisni, A. Maresca, P.C. Mcdonald, L. Yuanmei, Andrea Scozzafava, S. Dedhar, Jean-Yves Winum, Claudiu T. Supuran
- article
- Journal of Medicinal Chemistry, 2011, 54, pp.8271-8277. ⟨10.1021/jm200983e⟩
- Accès au bibtex
-
- titre
- Carbonic anhydrase activators: gold nanoparticles coated with derivatized histamine, histidine and carnosine show enhanced activatory effects on several mammalian isoforms.
- auteur
- Mohamed Chiheb Saada, Jean-Louis Montero, Daniela Vullo, Andrea Scozzafava, Jean-Yves Winum, Claudiu T. Supuran
- article
- Journal of Medicinal Chemistry, 2011, 54, pp.1170-1177. ⟨10.1021/jm101284a⟩
- Accès au bibtex
-
- titre
- Carbonic anhydrase I and II activation with mono- and dihalogenated histamine derivatives.
- auteur
- Mohamed Chiheb Saada, Daniela Vullo, Jean-Louis Montero, Andrea Scozzafava, Jean-Yves Winum, Claudiu T. Supuran
- article
- Bioorganic and Medicinal Chemistry Letters, 2011, 21, pp.4884-4887. ⟨10.1016/j.bmcl.2011.06.030⟩
- Accès au bibtex
-
- titre
- Sulfonamides incorporating boroxazolidone moieties are potent inhibitors of the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII.
- auteur
- Marouan Rami, A. Maresca, Fatma-Zohra Smaine, Jean-Louis Montero, Andrea Scozzafava, Jean-Yves Winum, Claudiu T. Supuran
- article
- Bioorganic and Medicinal Chemistry Letters, 2011, 21, pp.2975-2979. ⟨10.1016/j.bmcl.2011.03.055⟩
- Accès au bibtex
-
- titre
- Synthesis of rhodamine B - benzenesulfonamide conjugates and their inhibitory activity against human alpha- and bacterial/fungal beta-carbonic anhydrases.
- auteur
- Marouan Rami, Alessio Innocenti, Jean-Louis Montero, Andrea Scozzafava, Jean-Yves Winum, Claudiu T. Supuran
- article
- Bioorganic and Medicinal Chemistry Letters, 2011, 21, pp.5210-5213. ⟨10.1016/j.bmcl.2011.07.045⟩
- Accès au bibtex
-
2010
Journal articles
- titre
- Brucella Carbonic Anhydrases: New Targets for Designing Anti-Infective Agents
- auteur
- Jean-Yves Winum, Claudiu T. Supuran, Stephan Köhler
- article
- Current Pharmaceutical Design, 2010, 16 (29), pp.3310-3316. ⟨10.2174/138161210793429850⟩
- Accès au bibtex
-
- titre
- Inhibition studies of a beta-carbonic anhydrase from Brucella suis with a series of water soluble glycosyl sulfanilamides.
- auteur
- Daniela Vullo, Isao Nishimori, Andrea Scozzafava, Stephan Köhler, Jean-Yves Winum, Claudiu T Supuran
- article
- Bioorganic and Medicinal Chemistry Letters, 2010, 20 (7), pp.2178-82. ⟨10.1016/j.bmcl.2010.02.042⟩
- Accès au bibtex
-
- titre
- Cloning, characterization, and inhibition studies of a beta-carbonic anhydrase from Brucella suis.
- auteur
- Pascale Joseph, François Turtaut, Safia Ouahrani-Bettache, Jean-Louis Montero, Isao Nishimori, Tomoko Minakuchi, Daniela Vullo, Andrea Scozzafava, Stephan Köhler, Jean-Yves Winum, Claudiu T Supuran
- article
- Journal of Medicinal Chemistry, 2010, 53 (5), pp.2277-85. ⟨10.1021/jm901855h⟩
- Accès au bibtex
-
- titre
- Carbonic anhydrase inhibitors. X-ray crystallographic and solution binding studies for the interaction of a boron containing aromatic sulfamide with mammalian isoforms I-XV.
- auteur
- Anna Di Fiore, Simona Maria Monti, Alessio Innocenti, Jean-Yves Winum, Giuseppina de Simone, Claudiu T. Supuran
- article
- Bioorganic and Medicinal Chemistry Letters, 2010, 20, pp.3601-3605. ⟨10.1016/j.bmcl.2010.04.114⟩
- Accès au bibtex
-
- titre
- Carbonic anhydrase inhibitors : Gd(III) complexes of DOTA- and TETA- sulfonamide conjugates targeting the tumor associated carbonic anhydrase isozymes IX and XII
- auteur
- Marouan Rami, Jean-Louis Montero, Loic Dubois, P. Lambin, Andrea Scozzafava, Daniela Vullo, Jean-Yves Winum, Claudiu T. Supuran
- article
- New Journal of Chemistry, 2010, 34, pp.2139-2144. ⟨10.1039/C0NJ00214C⟩
- Accès au bibtex
-
Patents
- titre
- Carbonic anhydrase inhibitors with antimetastatic activity.
- auteur
- Claudiu T. Supuran, S. Dedhar, F. Carta, Jean-Yves Winum
- article
- Patent n° : 61/417,449. 2010
- Accès au bibtex
-
- titre
- Cancer targeting using carbonic anhydrase isoform IX inhibitors.
- auteur
- Loic Dubois, P. Lambin, Claudiu T. Supuran, Jean-Yves Winum
- article
- Patent n° : 1038473. 2010
- Accès au bibtex
-
- titre
- Inhibiteurs de l'histidinol déshydrogénase et leur utilisation en tant que médicament.
- auteur
- Jean-Yves Winum, Stephen Kohler, Jean-Louis Montero
- article
- France, N° de brevet: FR 2938252 A1. 2010
- Accès au bibtex
-
2009
Journal articles
- titre
- Carbonic anhydrase activators: Activation of human isozymes I, II and IX with phenylsulfonylhydrazido L-histidine derivatives
- auteur
- Marie-Rose Abdo, Daniela Vullo, Mohamed Chiheb Saada, Jean-Louis Montero, Andrea Scozzafava, Jean-Yves Winum, Claudiu T. Supuran
- article
- Bioorganic and Medicinal Chemistry Letters, 2009, 19, pp.2440-2443. ⟨10.1016/j.bmcl.2009.03.050⟩
- Accès au bibtex
-
- titre
- Inhibition of carbonic anhydrase IX : a new strategy against cancer
- auteur
- Jean-Yves Winum, Andrea Scozzafava, Jean-Louis Montero, Claudiu T. Supuran
- article
- Anti-Cancer Agents in Medicinal Chemistry, 2009, 9 (6), pp.693-702. ⟨10.2174/187152009788680028⟩
- Accès au bibtex
-
- titre
- tert-butyl N-[N,Nbis(2-chloroethyl)sulfamoyl]-N-(2-chloroethyl)carbamate
- auteur
- Achour Seridi, Hocine Akkari, Jean-Yves Winum, Patricia Benard-Rocherulle, Mohamed Abdaoui
- article
- Acta Crystallographica Section E : Structure Reports Online [2001-2014], 2009, E65 (10), pp.o2543-o2544. ⟨10.1107/S1600536809038185⟩
- Accès au bibtex
-
- titre
- Carbonic anhydrase inhibitors : glycosylsulfanilamides act as subnanomolar inhibitors of the human secreted isoform VI
- auteur
- Jean-Yves Winum, Jean-Louis Montero, Daniela Vullo, Claudiu T. Supuran
- article
- Chemical Biology and Drug Design, 2009, 74 (6), pp.636-639. ⟨10.1111/j.1747-0285.2009.00902.x⟩
- Accès au bibtex
-
- titre
- Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and cryptococcus neoformans with boronic acids
- auteur
- Alessio Innocenti, Jean-Yves Winum, Rebecca A. Hall, Fritz A. Muhlschlegel, Andrea Scozzafava, Claudiu T. Supuran
- article
- Bioorganic and Medicinal Chemistry Letters, 2009, 19 (10), pp.2642-2645. ⟨10.1016/j.bmcl.2009.03.147⟩
- Accès au bibtex
-
- titre
- Carbonic anhydrase inhibitors ; fluorinated phenyl sulfamates show strong inhibitory activity and selectivity for the inhibition of the tumor-associated isozyùes IX and XII over the cytosolic ones I and II
- auteur
- Jean-Yves Winum, Alessio Innocenti, Daniela Vullo, Jean-Louis Montero, Claudiu T. Supuran
- article
- Bioorganic and Medicinal Chemistry Letters, 2009, 19 (17), pp.5082-5085. ⟨10.1016/j.bmcl.2009.07.056⟩
- Accès au bibtex
-
- titre
- Therapeutic applications of glycosidic carbonic anhydrase inhibitors
- auteur
- Jean-Yves Winum, Sally-Ann Poulsen, Claudiu T. Supuran
- article
- Medicinal Research Reviews, 2009, 29 (3), pp.419-425. ⟨10.1002/med.20141⟩
- Accès au bibtex
-
- titre
- Expeditious stereoselective synthesis of L-iminosugars precursors via a Mitsunobu reaction
- auteur
- Antoine Bussière, Véronique Barragan-Montero, Khalid Null Oumzil, Jean-Yves Winum, Jean-Louis Montero
- article
- SYNLETT, 2009, 6, pp.978-980. ⟨10.1055/s-0028-1088209⟩
- Accès au bibtex
-
- titre
- Carbonic anhydrase inhibitors : comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors
- auteur
- Rosa Maria Vitale, Vincenzo Alterio, Alessio Innocenti, Jean-Yves Winum, Simona Maria Monti, Giuseppina de Simone, Claudiu T. Supuran
- article
- Journal of Medicinal Chemistry, 2009, 52 (19), pp.5990-5998. ⟨10.1021/jm900641r⟩
- Accès au bibtex
-
- titre
- Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isoforms I and II and transmembrane, tumor-associated isoforms IX and XII with boronic acids
- auteur
- Jean-Yves Winum, Alessio Innocenti, Andrea Scozzafava, Jean-Louis Montero, Claudiu T. Supuran
- article
- Bioorganic and Medicinal Chemistry, 2009, 17, pp.3649-3652. ⟨10.1016/j.bmc.2009.03.058⟩
- Accès au bibtex
-
Book sections
- titre
- Inhibitors of Histidinol dehydrogenases as antibacterial agents.
- auteur
- Pierre Joseph, François Turtaut, Stephen Kohler, Jean-Yves Winum
- article
- Wiley. In Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural, and Disease Applications., Hoboken, pp.937-951, 2009
- Accès au bibtex
-
- titre
- Zinc binding function in the design of carbonic anhydrase inhibitors.
- auteur
- Jean-Yves Winum, Jean-Louis Montero, Andrea Scozzafava, Claudiu T. Supuran
- article
- Wiley. In Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural, and Disease Applications, Hoboken, pp.39-73, 2009
- Accès au bibtex
-
- titre
- Selectivity issues in the design of CA inhibitors.
- auteur
- Claudiu T. Supuran, Jean-Yves Winum
- article
- Wiley. In Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural, and Disease Applications, Hoboken, pp.399-415, 2009
- Accès au bibtex
-
- titre
- APOBEC3G: a promising antiviral target.
- auteur
- Claudiu T. Supuran, Jean-Yves Winum
- article
- Wiley. In Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural, and Disease Applications., Hoboken, pp.981-989, 2009
- Accès au bibtex
-
- titre
- Introduction to zinc enzymes as drug targets.
- auteur
- Claudiu T. Supuran, Jean-Yves Winum
- article
- Wiley. In Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural, and Disease Applications., Hoboken, pp.3-12, 2009
- Accès au bibtex
-
Books
- titre
- Drug design of Zinc-enzyme inhibitors: functional, structural and disease applications
- auteur
- Claudiu T. Supuran, Jean-Yves Winum
- article
- John Wiley and Sons. John Wiley and Sons, pp.1038, 2009, Binghe Wang Series in drug discovery and Development
- Accès au bibtex
-
Patents
- titre
- Carbonic anhydrase isoform IX inhibitor coated nanoparticles and uses thereof.
- auteur
- Claudiu T. Supuran, Andrea Scozzafava, Jan Alexander Villadsen, Erik O. Pettersen, Peter Ebbesen, Jean-Yves Winum
- article
- Patent n° : 61/258,988. 2009
- Accès au bibtex
-
2008
Journal articles
- titre
- Brucella suis histidinol dehydrogenase: Synthesis and inhibition studies of substituted N-L-histidinylphenylsulfonyl hydrazide
- auteur
- Marie-Rose Abdo, Pascale Joseph, Rose-Anne Boigegrain, Jean-Louis Montero, Stephan Köhler, Jean-Yves Winum
- article
- Journal of Enzyme Inhibition and Medicinal Chemistry, 2008, 23 (3), pp.357-361. ⟨10.1080/14756360701617107⟩
- Accès au texte intégral et bibtex
-
- titre
- Carbonic anhydrase inhibitors. N-Cyanomethylsulfonamides—a new zinc binding group in the design of inhibitors targeting cytosolic and membrane-anchored isoforms
- auteur
- Jean-Yves Winum, Alessandro Cecchi, Achour Seridi, Andrea Scozzafava, Jean-Louis Montero, Claudiu Supuran
- article
- Journal of Enzyme Inhibition and Medicinal Chemistry, 2008, 21 (4), pp.477-481. ⟨10.1080/14756360600642370⟩
- Accès au bibtex
-
- titre
- Carbonic Anhydrase Inhibitors: Aliphatic N-phosphorylated Sulfamates--A Novel Zinc-anchoring Group Leading to Nanomolar Inhibitors
- auteur
- Laurent Bonnac, Alessio Innocenti, Jean-Yves Winum, Angela Casini, Jean-Louis Montero, Andrea Scozzafava, Veronique Barragan, Claudiu Supuran
- article
- Journal of Enzyme Inhibition and Medicinal Chemistry, 2008, 19 (3), pp.275-278. ⟨10.1080/14756360410001689522⟩
- Accès au bibtex
-
- titre
- Carbonic anhydrase inhibitors. Design of membrane-impermeant copper(II) complexes of DTPA-, DOTA- and TETA-tailed sulfonamides targeting the tumor-associated transmembrane isoforme IX.
- auteur
- Marouan Rami, Alessandro Cecchi, Jean-Louis Montero, Alessio Innocenti, Daniela Vullo, Andrea Scozzafava, Jean-Yves Winum, Claudiu T. Supuran
- article
- ChemMedChem, 2008, 3, pp.1780-1788. ⟨10.1002/cmdc.200800267⟩
- Accès au bibtex
-
- titre
- Design of zinc binding function for carbonic anhydrase inhibitors
- auteur
- Jean-Yves Winum, Andrea Scozzafava, Jean-Louis Montero, Claudiu T. Supuran
- article
- Current Pharmaceutical Design, 2008, 14, pp.615-621. ⟨10.2174/138161208783877848⟩
- Accès au bibtex
-
- titre
- Targeting bacterial metalloenzymes : a new strategy for the development of anti-infective agents.
- auteur
- Jean-Yves Winum, Stephen Kohler, Andrea Scozzafava, Jean-Louis Montero, Claudiu T. Supuran
- article
- Anti-Infective Agents, 2008, 7, pp.169-179. ⟨10.2174/187152108784911232⟩
- Accès au bibtex
-
- titre
- Carbonic anhydrase inhibitors. Design of spin-labeled sulfonamides incorporing TEMPO moieties as probes for cytosolic or transmembrane isozymes.
- auteur
- Alessandro Cecchi, L. Ciani, Jean-Yves Winum, Jean-Louis Montero, Andrea Scozzafava, S. Ristori, Claudiu T. Supuran
- article
- Bioorganic and Medicinal Chemistry Letters, 2008, 18, pp.3475-3480. ⟨10.1016/j.bmcl.2008.05.051⟩
- Accès au bibtex
-
- titre
- Carbonic anhydrase inhibitor coated gold nanoparticle selectively inhibit the tumor-associated isoform IX over the cytosolic ubiquitous isozymes I and II.
- auteur
- Maamar Stiti, Alessandro Cecchi, Marouan Rami, Mohamed Abdaoui, Véronique Barragan-Montero, Andrea Scozzafava, Yannick Guari, Jean-Yves Winum, Claudiu T. Supuran
- article
- Journal of the American Chemical Society, 2008, 130, pp.16130-16131. ⟨10.1021/ja805558k⟩
- Accès au bibtex
-
- titre
- Carbonic anhydrase inhibitors : 2-substituted-1,3,4-thiadiazole-5sulfamides act as powerful and selective inhibitors of the microchondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrase I, II and IV.
- auteur
- Fatma-Zohra Smaine, F. Pacchiano, Marouan Rami, Véronique Barragan-Montero, Daniela Vullo, Andrea Scozzafava, Jean-Yves Winum, Claudiu T. Supuran
- article
- Bioorganic and Medicinal Chemistry Letters, 2008, 18, pp.6332-6335. ⟨10.1016/j.bmcl.2008.10.093⟩
- Accès au bibtex
-
- titre
- Carbonic anhydrase inhibitors. Copper(II) complexes of polyamino-polycarboxylamido aromatic/heterocyclic sulfonamides are very potent inhibitors of the tumor associated isoforms IX and XII.
- auteur
- Marouan Rami, Jean-Yves Winum, Alessio Innocenti, Jean-Louis Montero, Andrea Scozzafava, Claudiu T. Supuran
- article
- Bioorganic and Medicinal Chemistry Letters, 2008, 18, pp.836-841. ⟨10.1016/j.bmcl.2007.11.025⟩
- Accès au bibtex
-
- titre
- Carbonic anhydrase IX : a new druggable target for the design of antitumor agents
- auteur
- Jean-Yves Winum, Marouan Rami, Andrea Scozzafava, Jean-Louis Montero, Claudiu T. Supuran
- article
- Medicinal Research Reviews, 2008, 28, pp.445-463. ⟨10.1002/med.20112⟩
- Accès au bibtex
-
2007
Journal articles
- titre
- Targeting of the Brucella suis virulence factor histidinol dehydrogenase by histidinol analogues results in inhibition of intramacrophagic multiplication of the pathogen.
- auteur
- Pascale Joseph, Marie-Rose Abdo, Rose-Anne Boigegrain, Jean-Louis Montero, Jean-Yves Winum, Stephan Köhler
- article
- Antimicrobial Agents and Chemotherapy, 2007, 51 (10), pp.3752-5. ⟨10.1128/AAC.00572-07⟩
- Accès au bibtex
-
- titre
- ETUDE DE LA RÉACTION DE MICHAELISARBUZOV SOUS ACTIVATION ULTRASONORE
- auteur
- Jean-Yves Winum, Mehrnaz Kamal, Huguette Agnaniet, Alain Leydet, Jean-Louis Montero
- article
- Phosphorus, Sulfur, and Silicon and the Related Elements, 2007, 129 (1), pp.83-88. ⟨10.1080/10426509708031583⟩
- Accès au bibtex
-
- titre
- Carbonic Anhydrase Inhibitors. The X-ray crystal structure of the adduct of N-hydroxysulfamide with isozyme II explains why this new zinc binding function is effective in the design of potent inhibitors
- auteur
- Claudia Temperini, Jean-Yves Winum, Jean-Louis Montero, Andrea Scozzafava, Claudiu T. Supuran
- article
- Bioorganic and Medicinal Chemistry Letters, 2007, 17, pp.2795-2801. ⟨10.1016/j.bmcl.2007.02.068⟩
- Accès au bibtex
-
- titre
- Synthesis of substituted N-aryl-N'-sulfamoyl-oxazolidin-2-ones with potential antibacterial activity
- auteur
- M. Nessaiba, Mohamed Abdaoui, A.G. Djahoudi, Mekki Kadri, Jean-Yves Winum
- article
- Recent Patents on Anti-Infective Drug Discovery, 2007, 2, pp.131-139. ⟨10.2174/157489107780832604⟩
- Accès au bibtex
-
- titre
- Carbonic anhydrase inhibitors: Binding of an antiglaucoma glycosyl-sulfanilamide derivative to human isoform II and its consequences for the drug design of enzyme inhibitors incorporating sugar moieties
- auteur
- Anna Di Fiore, Claudiu T. Supuran, Jean-Yves Winum, Jean-Louis Montero, Carlo Pedone, Andrea Scozzafava, Giuseppina de Simone
- article
- Bioorganic and Medicinal Chemistry Letters, 2007, 17, pp.1726-1731. ⟨10.1016/j.bmcl.2006.12.099⟩
- Accès au bibtex
-
- titre
- Carbonic Anhydrase Inhibitors. Inhibition of isoforms I, II, IV, VA, VII, IX and XIV with sulfonamides incorporating fructopyranose-thioureido tails
- auteur
- Jean-Yves Winum, A. Thiry, Khaled El Cheikh, J.M. Dogne, Jean-Louis Montero, Daniela Vullo, Andrea Scozzafava, B. Masereel, Claudiu T. Supuran
- article
- Bioorganic and Medicinal Chemistry Letters, 2007, 17, pp.2685-2691. ⟨10.1016/j.bmcl.2007.03.008⟩
- Accès au bibtex
-
- titre
- Carbonic anhydrase inhibitors. Selective inhibition of the extracellular, tumor-associated isoforms IX and XII over the cytosolic ones I and II with glycosylthioureido-sulfonamides
- auteur
- Fatma-Zohra Smaine, Jean-Yves Winum, Jean-Louis Montero, Daniela Vullo, Zine Regainia, Andrea Scozzafava, Claudiu T. Supuran
- article
- Bioorganic and Medicinal Chemistry Letters, 2007, 17, pp.5096-5100. ⟨10.1016/j.bmcl.2007.07.019⟩
- Accès au bibtex
-
- titre
- Brucella suis histidinol dehydrogenase: Synthesis and inhibition studies of a series of substituted benzylic ketones derivated from histidine
- auteur
- Marie-Rose Abdo, Pascale Joseph, R.A. Boigegrain, Jean-Pierre Liautard, Jean-Louis Montero, Stephen Kohler, Jean-Yves Winum
- article
- Bioorganic and Medicinal Chemistry, 2007, 15, pp.4427-4433. ⟨10.1016/j.bmc.2007.04.027⟩
- Accès au bibtex
-
- titre
- Carbonic anhydrase IX inhibitors: Fluorescent sulfonamides as therapeutic and diagnostic agents
- auteur
- Jean-Yves Winum
- article
- Expert Opinion on Therapeutic Patents, 2007, 17, pp.1393-1396. ⟨10.1517/13543776.17.11.1393⟩
- Accès au bibtex
-
- titre
- Metal binding functions in the design of carbonic anhydrase inhibitors
- auteur
- Jean-Yves Winum, Andrea Scozzafava, Jean-Louis Montero, Claudiu T. Supuran
- article
- Current Topics in Medicinal Chemistry, 2007, 7, pp.835-848. ⟨10.2174/156802607780636771⟩
- Accès au bibtex
-
2006
Journal articles
- titre
- Carbonic Anhydrase Inhibitors: Clash with Ala65 as a Means for Designing Inhibitors with Low Affinity for the Ubiquitous Isozyme II, Exemplified by the Crystal Structure of the Topiramate Sulfamide Analogue
- auteur
- Jean-Yves Winum, Claudia Temperini, Khaled El Cheikh, Alessio Innocenti, Daniela Vullo, Samuele Ciattini, Jean-Louis Montero, Andrea Scozzafava, Claudiu Supuran
- article
- Journal of Medicinal Chemistry, 2006, 49 (24), pp.7024-7031. ⟨10.1021/jm060807n⟩
- Accès au bibtex
-
- titre
- Therapeutic potential of sulfamides as enzyme inhibitors
- auteur
- Jean-Yves Winum, Andrea Scozzafava, Jean-Louis Montero, Claudiu Supuran
- article
- Medicinal Research Reviews, 2006, 26 (6), pp.767-792. ⟨10.1002/med.20068⟩
- Accès au bibtex
-
- titre
- SYNTHESIS AND BIOLOGICAL ACTIVITY OF A RETINYL PHOSPHONIC ACID DERIVATIVE AN ANALOG OF RETINYL PHOSPHATE: HOMORETINYLPHOSPHONIC ACID
- auteur
- Mehrnaz Kamal, Jean-Yves Winum, Véronique Barragan, Alain Leydet, Jean-Louis Montero
- article
- Phosphorus, Sulfur, and Silicon and the Related Elements, 2006, 152 (1), pp.241-256. ⟨10.1080/10426509908031633⟩
- Accès au bibtex
-
- titre
- A Simple, General and Efficient Method for O and N-Retinoylation. Application to The Synthesis of 2-Retinoyl-Lecithin
- auteur
- Charles Sangmam, Jean-Yves Winum, Marc Lucas, Jean-Louis Montero, Claude Chavis
- article
- Synthetic Communications, 2006, 28 (16), pp.2945-2958. ⟨10.1080/00397919808004874⟩
- Accès au bibtex
-
- titre
- N ‐Chlorosulfonyloxazolidin‐2‐ones: Synthesis, Structure, and Reactivity Toward Aminoesters
- auteur
- Malika Berredjem, Jean‐Yves Winum, Loic Toupet, Ouafae Masmoudi, Nour‐eddine Aouf, Jean‐louis Montero
- article
- Synthetic Communications, 2006, 34 (9), pp.1653-1662. ⟨10.1081/SCC-120030753⟩
- Accès au bibtex
-
- titre
- Carbonic Anhydrase Inhibitors: Hypoxia-Activatable Sulfonamides Incorporating Disulfide Bonds that Target the Tumor-Associated Isoform IX
- auteur
- Giuseppina de Simone, Rosa Maria Vitale, Anna Di Fiore, Carlo Pedone, Andrea Scozzafava, Jean-Louis Montero, Jean-Yves Winum, Claudiu Supuran
- article
- Journal of Medicinal Chemistry, 2006, 49 (18), pp.5544-5551. ⟨10.1021/jm060531j⟩
- Accès au bibtex
-
- titre
- New Zinc Binding Motifs in the Design of Selective Carbonic Anhydrase Inhibitors
- auteur
- Jean-Yves Winum, Andrea Scozzafava, Jean-Louis Montero, Claudiu Supuran
- article
- Mini-Reviews in Medicinal Chemistry, 2006, 6 (8), pp.921-936. ⟨10.2174/138955706777934946⟩
- Accès au bibtex
-
- titre
- Efficient Synthesis of Chiral 1,1′‐Sulfonyl Bisaziridines
- auteur
- Nawel Khettache, Amel Bendjeddou, Malika Berredjem, Zine Regainia, Veronique Montero, Chantal Menut, Nour‐eddine Aouf, Jean‐Yves Winum
- article
- Synthetic Communications, 2006, 36 (16), pp.2299-2305. ⟨10.1080/00397910600639802⟩
- Accès au bibtex
-
- titre
- Synthesis and Pharmacological Evaluation of Novel Nitrobenzenic Thromboxane Modulators as Antiplatelet Agents Acting on Both the Alpha and Beta Isoforms of the Human Thromboxane Receptor
- auteur
- Julien Hanson, Denis Reynaud, Na Qiao, Philippe Devel, Anne-Lise Moray, Jean-François Renard, Leanne Kelley, Jean-Yves Winum, Jean-Louis Montero, B. Therese Kinsella, Bernard Pirotte, Cecil Pace-Asciak, Jean-Michel Dogné
- article
- Journal of Medicinal Chemistry, 2006, 49 (12), pp.3701-3709. ⟨10.1021/jm060108a⟩
- Accès au bibtex
-
- titre
- Kinetic investigation on aqueous decomposition of 2-chloroethylnitrososulfamide
- auteur
- Achour Seridi, Mekki Kadri, Mohamed Abdaoui, Jean-Yves Winum, Jean-Louis Montero
- article
- Bioorganic and Medicinal Chemistry Letters, 2006, 16 (4), pp.1021-1027. ⟨10.1016/j.bmcl.2005.10.080⟩
- Accès au bibtex
-
- titre
- Kinetic investigation on aqueous decomposition of 2-chloroethylnitrososulfamide
- auteur
- Achour Seridi, Mekki Kadri, Mohamed Abdaoui, Jean-Yves Winum, Jean-Louis Montero
- article
- Bioorganic and Medicinal Chemistry Letters, 2006, 16 (4), pp.1021-1027. ⟨10.1016/j.bmcl.2005.10.080⟩
- Accès au bibtex
-
- titre
- Study on the decomposition of 2-chloroethylnitrososulfamides (CENS) in serum using HPLC on-line solid phase extraction
- auteur
- Jean-Louis Montero, Mohamed Abdaoui, Mekki Kadri, Achour Seridi, Jean-Yves Winum
- article
- Archiv der Pharmazie / Arch Pharm Pharm Med Chem; Arch Pharm Chem Life Sci; Arch Pharm (Weinheim), 2006, 339, pp.521-526
- Accès au bibtex
-
- titre
- Kinetic investigation on aqueous decomposition of 2-chloroethylnitrososulamide
- auteur
- Achour Seridi, Mekki Kadri, Mohamed Abdaoui, Jean-Yves Winum, Jean-Louis Montero
- article
- Bioorganic and Medicinal Chemistry Letters, 2006, 16, pp.1021-1027
- Accès au bibtex
-
- titre
- The sulfamide motif in the design of enzyme inhibitors
- auteur
- Jean-Yves Winum, Andrea Scozzafava, Jean-Louis Montero, Claudiu T. Supuran
- article
- Expert Opinion on Therapeutic Patents, 2006, 16, pp.27-47
- Accès au bibtex
-
- titre
- Carbonic anhydrase inhibitors : Hypoxia-Activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX
- auteur
- Giuseppina de Simone, Rosa Maria Vitale, Anna Di Fiore, Carlo Pedone, Andrea Scozzafava, Jean-Louis Montero, Jean-Yves Winum, Claudiu T. Supuran
- article
- Journal of Medicinal Chemistry, 2006, 49, pp.5544-5551
- Accès au bibtex
-
- titre
- New zinc binding motifs in the design of selective carbonic anhydrase inhibitors
- auteur
- Jean-Yves Winum, Andrea Scozzafava, Jean-Louis Montero, Claudiu T. Supuran
- article
- Mini-Reviews in Medicinal Chemistry, 2006, 6, pp.921-936
- Accès au bibtex
-
- titre
- Carbonic anhydrase inhibitors. N-cyanomethylsulfonamides-a new zinc binding group in the design of inhibitors targeting cytosolic and membrane-anchored isoforms
- auteur
- Jean-Yves Winum, Alessandro Cecchi, Achour Seridi, Andrea Scozzafava, Jean-Louis Montero, Claudiu T. Supuran
- article
- Journal of Enzyme Inhibition and Medicinal Chemistry, 2006, 21, pp.477-481
- Accès au bibtex
-
- titre
- Efficient Synthesis of Chiral 1,1′-Sulfonyl Bisaziridines
- auteur
- Nawel Khettache, Amel Bendjeddou, Malika Berredjem, Zine Regainia, Jean-Yves Winum, Chantal Menut, Nour-Eddine Aouf, Véronique Barragan-Montero
- article
- Synthetic Communications, 2006, 36, pp.2299-2305
- Accès au bibtex
-
- titre
- Synthesis and pharmacological evaluation of novel nitrobenzenic thromboxane modulators as antiplatelet agents acting on both the alpha and beta isoforms of the human thromboxane receptor.
- auteur
- Julien Hanson, Denis Reynaud, Na Qiao, Philippe Devel, Anne-Lise Moray, Jean-François Renard, Leanne P. Kelley, Jean-Yves Winum, Jean-Louis Montero, B. Thérèse Kinsella, Bernard Pirotte, Cecil R. Pace-Asciak, Jean-Michel Dogné
- article
- Journal of Medicinal Chemistry, 2006, 49, pp.3701-3709
- Accès au bibtex
-
- titre
- Carbonic anhydrase inhibitors : Clash with Ala65 as a Means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue
- auteur
- Jean-Yves Winum, Claudia Temperini, Khaled El Cheikh, Alessio Innocenti, Daniela Vullo, Samuele Ciattini, Jean-Louis Montero, Andrea Scozzafava, Claudiu T. Supuran
- article
- Journal of Medicinal Chemistry, 2006, 49, pp.7024-7031
- Accès au bibtex
-
- titre
- Therapeutic potential of sulfamides as enzyme inhibitors
- auteur
- Jean-Yves Winum, Andrea Scozzafava, Jean-Louis Montero, Claudiu T. Supuran
- article
- Medicinal Research Reviews, 2006, 26, pp.767-792
- Accès au bibtex
-
2005
Journal articles
- titre
- The sulfamide motif in the design of enzyme inhibitors
- auteur
- Jean-Yves Winum, Andrea Scozzafava, Jean-Louis Montero, Claudiu Supuran
- article
- Expert Opinion on Therapeutic Patents, 2005, 16 (1), pp.27-47. ⟨10.1517/13543776.16.1.27⟩
- Accès au bibtex
-
- titre
- Synthesis and properties of isocannabinoid and cholesterol derivatized rhamnosurfactants: application to liposomal targeting of keratinocytes and skin
- auteur
- Véronique Barragan-Montero, Jean-Yves Winum, Jean-Pierre Molès, Emmanuelle Juan, Caroline Clavel, Jean-Louis Montero
- article
- European Journal of Medicinal Chemistry, 2005, 40 (10), pp.1022-1029. ⟨10.1016/j.ejmech.2005.04.009⟩
- Accès au bibtex
-
- titre
- Carbonic Anhydrase Inhibitors. Design of Fluorescent Sulfonamides as Probes of Tumor-Associated Carbonic Anhydrase IX That Inhibit Isozyme IX-Mediated Acidification of Hypoxic Tumors
- auteur
- Alessandro Cecchi, Alzbeta Hulikova, Jaromír Pastorek, Silvia Pastoreková, Andrea Scozzafava, Jean-Yves Winum, Jean-Louis Montero, Claudiu Supuran
- article
- Journal of Medicinal Chemistry, 2005, 48 (15), pp.4834-4841. ⟨10.1021/jm0501073⟩
- Accès au bibtex
-
- titre
- Carbonic anhydrase inhibitors. Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with boron-containing sulfonamides, sulfamides, and sulfamates: Toward agents for boron neutron capture therapy of hypoxic tumors
- auteur
- Jean-Yves Winum, Alessandro Cecchi, Jean-Louis Montero, Alessio Innocenti, Andrea Scozzafava, Claudiu Supuran
- article
- Bioorganic and Medicinal Chemistry Letters, 2005, 15 (13), pp.3302-3306. ⟨10.1016/j.bmcl.2005.04.058⟩
- Accès au bibtex
-
- titre
- Carbonic anhydrase inhibitors: Novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of the cytosolic and tumour-associated carbonic anhydrase isozymes I, II and IX
- auteur
- Vladimir Garaj, Luca Puccetti, Giuseppe Fasolis, Jean-Yves Winum, Jean-Louis Montero, Andrea Scozzafava, Daniela Vullo, Alessio Innocenti, Claudiu Supuran
- article
- Bioorganic and Medicinal Chemistry Letters, 2005, 15 (12), pp.3102-3108. ⟨10.1016/j.bmcl.2005.04.056⟩
- Accès au bibtex
-
- titre
- Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxysulfamides—a new zinc-binding function in the design of inhibitors
- auteur
- Jean-Yves Winum, Alessio Innocenti, Jihane Nasr, Jean-Louis Montero, Andrea Scozzafava, Daniela Vullo, Claudiu Supuran
- article
- Bioorganic and Medicinal Chemistry Letters, 2005, 15 (9), pp.2353-2358. ⟨10.1016/j.bmcl.2005.02.091⟩
- Accès au bibtex
-
- titre
- Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds
- auteur
- Luca Puccetti, Giuseppe Fasolis, Alessandro Cecchi, Jean-Yves Winum, Alessandro Gamberi, Jean-Louis Montero, Andrea Scozzafava, Claudiu Supuran
- article
- Bioorganic and Medicinal Chemistry Letters, 2005, 15 (9), pp.2359-2364. ⟨10.1016/j.bmcl.2005.02.087⟩
- Accès au bibtex
-
- titre
- Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with organic phosphates and phosphonates
- auteur
- Jean-Yves Winum, Alessio Innocenti, Valerie Gagnard, Jean-Louis Montero, Andrea Scozzafava, Daniela Vullo, Claudiu Supuran
- article
- Bioorganic and Medicinal Chemistry Letters, 2005, 15 (6), pp.1683-1686. ⟨10.1016/j.bmcl.2005.01.049⟩
- Accès au bibtex
-
- titre
- Inclusion complexes of N-sulfamoyloxazolidinones with β-cyclodextrin
- auteur
- Jean-Yves Winum, Silvia Pastorekova, Lydia Jakubickova, Jean-Louis Montero, Andrea Scozzafava, Jaromir Pastorek, Daniela Vullo, Alessio Innocenti, Claudiu Supuran
- article
- Bioorganic and Medicinal Chemistry Letters, 2005, 15 (4), pp.889-894. ⟨10.1016/j.bmcl.2004.11.058⟩
- Accès au bibtex
-
- titre
- Carbonic anhydrase inhibitors : novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of the cytosolic and tumour-associated carbonic anhydrase isozymes I, II and IX
- auteur
- Vladimir Garaj, Luca Puccetti, Giuseppe Fasolis, Jean-Yves Winum, Jean-Louis Montero, Andrea Scozzafava, Daniela Vullo, Alessio Innocenti, Claudiu T. Supuran
- article
- Bioorganic and Medicinal Chemistry Letters, 2005, 15, pp.3102-3108
- Accès au bibtex
-
- titre
- Inclusion complexes of N-sulfamoyloxazolidinones with β-cyclodextrin
- auteur
- Mekki Kadri, Rayenne Djemil, Mohamed Abdaouui, Jean-Yves Winum, Frédéric Coutrot, Jean-Louis Montero
- article
- Bioorganic and Medicinal Chemistry Letters, 2005, 15, pp.889-894. ⟨10.1016/j.bmcl.2004.12.060⟩
- Accès au bibtex
-
- titre
- Carbonic anhydrase inhibitors : synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II and IX with bis-sulfamates
- auteur
- Jean-Yves Winum, Silvia Pastorekova, Lydia Jakubickova, Jean-Louis Montero, Andrea Scozzafava, Jaromir Pastorek, Daniela Vullo, Alessio Innocenti, Claudiu T. Supuran
- article
- Bioorganic and Medicinal Chemistry Letters, 2005, 15, pp.579-584
- Accès au bibtex
-
- titre
- Carbonic anhydrase inhibitors : synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds
- auteur
- Luca Puccetti, Giuseppe Fasolis, Alessandro Cecchi, Jean-Yves Winum, Alessandro Gamberi, Jean-Louis Montero, Andrea Scozzafava, Claudiu T. Supuran
- article
- Bioorganic and Medicinal Chemistry Letters, 2005, 15, pp.2359-2364
- Accès au bibtex
-
- titre
- Carbonic anhydrase inhibitors : synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II and IX with sulfonamides incorporating hydrazino moities
- auteur
- Jean-Louis Montero, Andrea Scozzafava, Claudiu T. Supuran, Daniela Vullo, Jean-Yves Winum, Jean-Michel Dogné, Angela Casini, Xavier de Leval, Alession Innocenti
- article
- Journal of Medicinal Chemistry, 2005, 48, pp.2121-2125
- Accès au bibtex
-
- titre
- Carbonic anhydrase inhibitors. Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with boron-containing sulfonamides, sulfamides, and sulfamates : toward agents for boron neutron capture therapy of hypoxic tumors
- auteur
- Jean-Yves Winum, Alessandro Cecchi, Jean-Louis Montero, Alessio Innocenti, Andrea Scozzafava, Claudiu T. Supuran
- article
- Bioorganic and Medicinal Chemistry Letters, 2005, 15, pp.3302-3306
- Accès au bibtex
-
- titre
- Sulfamates and Their Therapeutic Potential
- auteur
- Jean-Yves Winum, Andrea Scozzafava, Jean-Louis Montero, Claudiu T. Supuran
- article
- Medicinal Research Reviews, 2005, 25, pp.186-228
- Accès au bibtex
-
- titre
- Synthesis and properties of isocannabinoid and cholesterol derivatized rhamnosurfactants : application to liposomal targeting of keratinocytes and skin
- auteur
- Véronique Barragan-Montero, Jean-Yves Winum, Jean-Pierre Molès, Emmanuelle Juan, Caroline Clavel, Jean-Louis Montero
- article
- European Journal of Medicinal Chemistry, 2005, 40, pp.1022-1029
- Accès au bibtex
-
- titre
- Carbonic anhydrase inhibitors : CA IX selective inhibitors incorporating aromatic or heterocyclic sulfonamide
- auteur
- Jean-Yves Winum
- article
- Expert Opinion on Therapeutic Patents, 2005, 15, pp.233-236
- Accès au bibtex
-
- titre
- Carbonic anhydrase inhibitors. Interaction of enzymes I, II, IV, V and IX with organic phosphates and phosphonates
- auteur
- Jean-Yves Winum, Alessio Innocenti, Valérie Gagnard, Jean-Louis Montero, Andrea Scozzafava, Daniela Vullo, Claudiu T. Supuran
- article
- Bioorganic and Medicinal Chemistry Letters, 2005, 15, pp.1683-1686
- Accès au bibtex
-
- titre
- Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as Probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors
- auteur
- Alessandro Cecchi, Alzbeta Hulikova, Jaromir Pastorek, Silvia Pastorekova, Andrea Scozzafava, Jean-Yves Winum, Jean-Louis Montero, Claudiu T. Supuran
- article
- Journal of Medicinal Chemistry, 2005, 48, pp.4834-4841
- Accès au bibtex
-
- titre
- Carbonic anhydrase inhibitors : synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX and XII with N-hydroxysulfamides-a new zinc-binding function in the design of inhibitors
- auteur
- Jean-Yves Winum, Alessio Innocenti, Jihane Nasr, Jean-Louis Montero, Andrea Scozzafava, Daniela Vullo, Claudiu T. Supuran
- article
- Bioorganic and Medicinal Chemistry Letters, 2005, 15, pp.2353-2358
- Accès au bibtex
-
2004
Journal articles
- titre
- Design, Synthesis, and Pharmacological Evaluation of Pyridinic Analogues of Nimesulide as Cyclooxygenase-2 Selective Inhibitors
- auteur
- Fabien Julémont, Xavier de Leval, Catherine Michaux, Jean-François Renard, Jean-Yves Winum, Jean-Louis Montero, Jacques Damas, Jean-Michel Dogné, Bernard Pirotte
- article
- Journal of Medicinal Chemistry, 2004, 47 (27), pp.6749-6759. ⟨10.1021/jm049480l⟩
- Accès au bibtex
-
- titre
- Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides derived from 4-isothiocyanato-benzolamide
- auteur
- Alessandro Cecchi, Jean-Yves Winum, Alessio Innocenti, Daniela Vullo, Jean-Louis Montero, Andrea Scozzafava, Claudiu Supuran
- article
- Bioorganic and Medicinal Chemistry Letters, 2004, 14 (23), pp.5775-5780. ⟨10.1016/j.bmcl.2004.09.062⟩
- Accès au bibtex
-
- titre
- Carbonic Anhydrase Inhibitors: Synthesis and Inhibition of Cytosolic/Membrane-Associated Carbonic Anhydrase Isozymes I, II, and IX with Sulfonamides Incorporating Hydrazino Moieties
- auteur
- Jean-Yves Winum, Jean-Michel Dogné, Angela Casini, Xavier de Leval, Jean-Louis Montero, Andrea Scozzafava, Daniela Vullo, Alessio Innocenti, Claudiu Supuran
- article
- Journal of Medicinal Chemistry, 2004, 48 (6), pp.2121-2125. ⟨10.1021/jm0494826⟩
- Accès au bibtex
-
- titre
- Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties
- auteur
- Vladimir Garaj, Luca Puccetti, Giuseppe Fasolis, Jean-Yves Winum, Jean-Louis Montero, Andrea Scozzafava, Daniela Vullo, Alessio Innocenti, Claudiu Supuran
- article
- Bioorganic and Medicinal Chemistry Letters, 2004, 14 (21), pp.5427-5433. ⟨10.1016/j.bmcl.2004.07.087⟩
- Accès au bibtex
-
- titre
- Sulfamates and their therapeutic potential
- auteur
- Jean‐Yves Winum, Andrea Scozzafava, Jean‐louis Montero, Claudiu Supuran
- article
- Medicinal Research Reviews, 2004, 25 (2), pp.186-228. ⟨10.1002/med.20021⟩
- Accès au bibtex
-
- titre
- New pyrophosphate analogues: a facile access to N-(O-alkyl-sulfamoyl)phosphoramidic acids via a simple and quantitative reaction of N-(O-alkylsulfamoyl)trimethylphospha-λ5-azene with bromotrimethylsilane and water
- auteur
- Laurent Bonnac, Véronique Barragan-Montero, Jean‐Yves Winum, Jean-Louis Montero
- article
- Tetrahedron, 2004, 60 (10), pp.2187-2190. ⟨10.1016/j.tet.2004.01.035⟩
- Accès au bibtex
-
- titre
- Carbonic anhydrase inhibitors: N-(p-sulfamoylphenyl)-α-d-glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits
- auteur
- Jean-Yves Winum, Angela Casini, Francesco Mincione, Michele Starnotti, Jean-Louis Montero, Andrea Scozzafava, Claudiu Supuran
- article
- Bioorganic and Medicinal Chemistry Letters, 2004, 14 (1), pp.225-229. ⟨10.1016/j.bmcl.2003.09.063⟩
- Accès au bibtex
-
- titre
- Inclusion complexes of 2-chloroethylnitrososulfamides (CENS) with β-cyclodextrin
- auteur
- Mekki Kadri, Nabila Dhaoui, Mohamed Abdaoui, Jean-Yves Winum, Jean-Louis Montero
- article
- European Journal of Medicinal Chemistry, 2004, 39 (1), pp.79-84. ⟨10.1016/j.ejmech.2003.11.003⟩
- Accès au bibtex
-
- titre
- Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with EMATE, a dual inhibitor of carbonic anhydrases and steroid sulfatase
- auteur
- Francesco Abbate, Jean-Yves Winum, Barry V.L. Potter, Angela Casini, Jean-Louis Montero, Andrea Scozzafava, Claudiu Supuran
- article
- Bioorganic and Medicinal Chemistry Letters, 2004, 14 (1), pp.231-234. ⟨10.1016/j.bmcl.2003.09.064⟩
- Accès au bibtex
-
- titre
- Carbonic anhydrase inhibitors : aliphatic N-phosphorylated sulfamates - A novel zinc-anchoring group leading to nanomolar inhibitors
- auteur
- Laurent Bonnac, Alessio Innocenti, Jean-Yves Winum, Angela Casini, Jean-Louis Montero, Andrea Scozzafava, Véronique Barragan, Claudiu T. Supuran
- article
- Journal of Enzyme Inhibition and Medicinal Chemistry, 2004, 19, pp.275-278
- Accès au bibtex
-
- titre
- Carbonic anhydrase inhibitors : N-(p-sulfamoyphenyl)-alpha-D-glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits
- auteur
- Jean-Yves Winum, Angela Casini, Francesco Mincione, Michele Starnotti, Jean-Louis Montero, Andrea Scozzafava, Claudiu T. Supuran
- article
- Bioorganic and Medicinal Chemistry Letters, 2004, 14, pp.225-229
- Accès au bibtex
-
- titre
- Therapeutic applications of sulfamates
- auteur
- Jean-Yves Winum, Andrea Scozzafava, Jean-Louis Montero, Claudiu T. Supuran
- article
- Expert Opinion on Therapeutic Patents, 2004, 14, pp.1273-1308
- Accès au bibtex
-
- titre
- N-chlorosulfonyloxazolidin-2-ones : synthesis, structure and reactivity toward aminoesters
- auteur
- Malika Berredjem, Jean-Yves Winum, Loic Toupet, Ouafae Masmoudi, Nour-Eddine Aouf, Jean-Louis Montero
- article
- Synthetic Communications, 2004, 34, pp.1653-1662
- Accès au bibtex
-
- titre
- New pyrophosphate analogues : a facile access to N-(O-alkyl-sulfamoyl)phosphoramidic acids via a simple and quantitative reaction of N-(O-alkylsulfamoyl)trimethylphospha-lambda5-azene with bromotrimethylsilane and water
- auteur
- Laurent Bonnac, Véronique Barragan, Jean-Yves Winum, Jean-Louis Montero
- article
- Tetrahedron, 2004, 60, pp.2187-2190
- Accès au bibtex
-
- titre
- Carbonic anhydrase inhibitors : synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II and IX with sulfonamides incorporating 1,2,4-triazine moieties
- auteur
- Vladimir Garaj, Luca Puccetti, Giuseppe Fasolis, Jean-Yves Winum, Jean-Louis Montero, Andrea Scozzafava, Daniela Vullo, Alessio Innocenti, Claudiu T. Supuran
- article
- Bioorganic and Medicinal Chemistry Letters, 2004, 14, pp.5427-5433
- Accès au bibtex
-
- titre
- Carbonic anhydrase inhibitors : synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II and IX with sulfonamides derived from 4-isothiocyanato-benzolamide
- auteur
- Alessandro Cecchi, Jean-Yves Winum, Alessio Innocenti, Daniela Vullo, Jean-Louis Montero, Andrea Scozzafava, Claudiu T. Supuran
- article
- Bioorganic and Medicinal Chemistry Letters, 2004, 14, pp.5775-5780
- Accès au bibtex
-
- titre
- Carbonic anhydrase inhibitors : X-ray crystallographic structure of the adduct of human isozyme II with EMATE, a dual inhibitor of carbonic anhydrases and steroid sulfatase
- auteur
- Francesco Abbate, Jean-Yves Winum, Barry V. L. Potter, Angela Casini, Jean-Louis Montero, Andrea Scozzafava, Claudiu T. Supuran
- article
- Bioorganic and Medicinal Chemistry Letters, 2004, 14, pp.231-234
- Accès au bibtex
-
- titre
- Inclusion complexes of 2-chloroethylnitrososulfamides (CENS) with beta-cyclodextrin
- auteur
- Mekki Kadri, Nabila Dhaoui, Mohamed Abdaoui, Jean-Yves Winum, Jean-Louis Montero
- article
- European Journal of Medicinal Chemistry, 2004, 39, pp.79-84
- Accès au bibtex
-
- titre
- Design, synthesis and pharmacological evaluation of pyridinic analogues of nimesulide as cyclooxygenase-2 selective inhibitors
- auteur
- Fabien Julémont, Xavier de Leval, Catherine Michaux, Jean-François Renard, Jean-Yves Winum, Jean-Louis Montero, Jacques Damas, Jean-Michel Dogné, Bernard Pirotte
- article
- Journal of Medicinal Chemistry, 2004, 47, pp.6749-6759
- Accès au bibtex
-
2003
Journal articles
- titre
- Cytotoxicity, DNA Damage, and Apoptosis Induced by New Fotemustine Analogs on Human Melanoma Cells in Relation to O 6 -Methylguanine DNA-Methyltransferase Expression
- auteur
- Isabelle Passagne, Alexandre Evrard, Jean-Yves Winum, Philippe Depeille, Pierre Cuq, Jean-Louis Montero, Didier Cupissol, Laurence Vian
- article
- Journal of Pharmacology and Experimental Therapeutics, 2003, 307 (2), pp.816-823. ⟨10.1124/jpet.103.051938⟩
- Accès au bibtex
-
- titre
- Carbonic Anhydrase Inhibitors: Inhibition of Transmembrane, Tumor-Associated Isozyme IX, and Cytosolic Isozymes I and II with Aliphatic Sulfamates
- auteur
- Jean-Yves Winum, Daniela Vullo, Angela Casini, Jean-Louis Montero, Andrea Scozzafava, Claudiu Supuran
- article
- Journal of Medicinal Chemistry, 2003, 46 (25), pp.5471-5477. ⟨10.1021/jm030911u⟩
- Accès au bibtex
-
- titre
- Carbonic Anhydrase Inhibitors. Inhibition of Cytosolic Isozymes I and II and Transmembrane, Tumor-Associated Isozyme IX with Sulfamates Including EMATE Also Acting as Steroid Sulfatase Inhibitors
- auteur
- Jean-Yves Winum, Daniela Vullo, Angela Casini, Jean-Louis Montero, Andrea Scozzafava, Claudiu Supuran
- article
- Journal of Medicinal Chemistry, 2003, 46 (11), pp.2197-2204. ⟨10.1021/jm021124k⟩
- Accès au bibtex
-
- titre
- Synthese et N-Acylation Regiospecifique de 1,2,5-Thiadiazolidines 1,1-Dioxydes Chirales
- auteur
- Malika Berredjem, Houria Djebbar, Zine Regainia, Nour-Eddine Aouf, Georges Dewynter, Jean-Yves Winum, Jean-Louis Montero
- article
- Phosphorus, Sulfur, and Silicon and the Related Elements, 2003, 178 (4), pp.693-705. ⟨10.1080/10426500307811⟩
- Accès au bibtex
-
- titre
- Synthesis and biological evaluation of Fotemustine analogues on human melanoma cell lines
- auteur
- Jean-Yves Winum, Jean-Luc Bouissière, Isabelle Passagne, Alexandre Evrard, Véronique Barragan-Montero, Pierre Cuq, Jean-Louis Montero
- article
- European Journal of Medicinal Chemistry, 2003, 38 (3), pp.319-324. ⟨10.1016/s0223-5234(03)00014-x⟩
- Accès au bibtex
-
- titre
- Synthesis and biological evaluation of Fotemustine analogues on human melanoma cell lines
- auteur
- Jean-Yves Winum, Jean-Luc Bouissière, Isabelle Passagne, Alexandre Evrard, Véronique Montero, Pierre Cuq, Jean-Louis Montero
- article
- European Journal of Medicinal Chemistry, 2003, 38 (3), pp.319-324. ⟨10.1016/s0223-5234(03)00014-x⟩
- Accès au bibtex
-
- titre
- Carbonic anhydrase inhibitors
- auteur
- Angela Casini, Jean-Yves Winum, Jean-Louis Montero, Andrea Scozzafava, Claudiu Supuran
- article
- Bioorganic and Medicinal Chemistry Letters, 2003, 13 (5), pp.837-840. ⟨10.1016/s0960-894x(03)00028-3⟩
- Accès au bibtex
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Patents
- titre
- Nouveaux tensio-actifs, compositions les comprenant
- auteur
- Véronique Barragan, Jean-Louis Montero, Jean-Yves Winum, Emmanuelle Juan, Jean-Pierre Molès
- article
- N° de brevet: FR 2003, 2854896. 2003
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2002
Journal articles
- titre
- Synthesis of new targretin® analogues that induce apoptosis in leukemia HL-60 cells
- auteur
- Jean-Yves Winum, Stephen Baghdiguian, Thérèse Commes, Alain Leydet, Jean-Louis Montero
- article
- Bioorganic and Medicinal Chemistry Letters, 2002, 12 (24), pp.3529-3532. ⟨10.1016/s0960-894x(02)00803-x⟩
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2001
Journal articles
- titre
- Synthesis and biological activity of glycosyl conjugates of N-(4-hydroxyphenyl)retinamide
- auteur
- Jean-Yves Winum, Alain Leydet, Michel Seman, Jean-Louis Montero
- article
- Il Farmaco (1989-2006), 2001, 56 (4), pp.319-324. ⟨10.1016/s0014-827x(01)01074-6⟩
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- titre
- A convenient method for the alkylation of sulfamides using alkyl bromides and Mitsunobu betaine
- auteur
- Jean-Yves Winum, Véronique Barragan, Jean-Louis Montero
- article
- Tetrahedron Letters, 2001, 42 (4), pp.601-603. ⟨10.1016/S0040-4039(00)02012-8⟩
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- titre
- N-(tert-butoxycarbonyl)-N-[4-(dimethylazaniumylidene)-1,4-dihydropyridin-1-ylsulfonyl]azanide: A new sulfamoylating Agent. Structure and Reactivity towards Amines
- auteur
- Jean-Yves Winum, Loic Toupet, Véronique Barragan, Georges Dewynter, Jean-Louis Montero
- article
- Organic Letters, 2001, 3, pp.2241-2243. ⟨10.1021/ol0161312⟩
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- titre
- A convenient method for the alkylation of sulfamide using alkyl bromide under Mitsunobu conditions
- auteur
- Jean-Yves Winum, Véronique Barragan, Jean-Louis Montero
- article
- Tetrahedron Letters, 2001, 42, pp.601-603
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1999
Journal articles
- titre
- Synthesis of Multiply Substituted, Ion Channel Forming Octi( p -phenylene)s: Theme and Variations
- auteur
- Fabien Robert, Jean-Yves Winum, Naomi Sakai, David Gerard, Stefan Matile
- article
- Organic Letters, 1999, 2 (1), pp.37-39. ⟨10.1021/ol991210n⟩
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- titre
- Rigid Push−Pull Oligo( p -Phenylene) Rods: Depolarization of Bilayer Membranes with Negative Membrane Potential
- auteur
- Jean-Yves Winum, Stefan Matile
- article
- Journal of the American Chemical Society, 1999, 121 (34), pp.7961-7962. ⟨10.1021/ja991133r⟩
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- titre
- Synthesis and biological activity homoretinylphosphonic acid
- auteur
- Jean-Louis Montero, Mernaz Kamal, Jean-Yves Winum, Véronique Barragan, Alain Leydet
- article
- Phosphorus, Sulfur, and Silicon and the Related Elements, 1999, 152, pp.241-256
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1998
Journal articles
- titre
- One-Pot Synthesis of Nucleosides Using Bismuth(III) Bromide as Catalyst.
- auteur
- Jean-Yves Winum, Mehrnaz Kamal, Véronique Barragan, Alain Leydet, Jean-Louis Montero
- article
- Synthetic Communications, 1998, 28 (4), pp.603-606. ⟨10.1080/00397919808005931⟩
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- titre
- One pot synthesis of nucleosides using Bismuth III bromide as catalyst
- auteur
- Jean-Yves Winum, Mernaz Kamal, Véronique Barragan, Alain Leydet, Jean-Louis Montero
- article
- Synthetic Communications, 1998, 28, pp.603-606
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1997
Journal articles
- titre
- Synthesis and biological activities of higher homologues of retinoic acid.
- auteur
- Jean-Yves Winum, M Kamal, H Defacque, T Commes, C Chavis, M Lucas, J Marti, J Montero
- article
- Il Farmaco (1989-2006), 1997, 52 (1), pp.39-42
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- titre
- A convenient synthesis of peracetylated glycosyl halides using bismuth(III) halides as catalysts
- auteur
- Jean-Yves Winum, Jean-Louis Montero, Alain Leydet, Mehrnaz Kamal, André Pavia, Jean-Pierre Roque
- article
- Carbohydrate Research, 1997, 297 (2), pp.175-180. ⟨10.1016/S0008-6215(96)00269-8⟩
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1996
Journal articles
- titre
- Homologation of carboxylic acids by arndt-eistert reaction under ultrasonic waves
- auteur
- Jean-Yves Winum, Merhnaz Kamal, Alain Leydet, Jean-Pierre Roque, Jean-Louis Montero
- article
- Tetrahedron Letters, 1996, 37 (11), pp.1781-1782. ⟨10.1016/0040-4039(96)00130-X⟩
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